Lipoxygenase, vertebrates, PLAT domain

Definition

Lipoxygenases (LOXs, LOs) catalyze the the dioxygenation of polyunsaturated fatty acids, including arachidonic acid. Animal LO enzymes include 5-LO, 12-LO (epidermal-, platelet-, and leukocyte-type), 15-LO, and eLOX-3 (epidermis-type LO-3). 12-LO and 15-LO and its metabolites participate in apoptosis, autophagy and ferroptosis, and have been implicated in the development of insulin resistance and diabetes [[cite:PMID:29627380], [cite:PMID:22951339]]. This entry represents the PLAT domain of vertebrate LOs PMID:10469604. 12-LO and 15-LO are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates [[cite:PMID:12106812], [cite:PMID:10672019], [cite:PMID:20970452]].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• ALOX12
• ALOX12B
• ALOX15
• ALOX15B
• ALOX5
• ALOXE3