LANCL1

Protein identityUniProt · HPA

UniProt accession

O43813

Gene

LANCL1

Ensembl

ENSG00000115365

Chromosome

2

Canonical length

399 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Microtubules,Primary cilium,Basal body,Flagellar centriole,End piece

OverviewNCBI Gene

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>O43813|LANCL1
     1  MAQRAFPNPY ADYNKSLAEG YFDAAGRLTP EFSQRLTNKI RELLQQMERG LKSADPRDGT
    61  GYTGWAGIAV LYLHLYDVFG DPAYLQLAHG YVKQSLNCLT KRSITFLCGD AGPLAVAAVL
   121  YHKMNNEKQA EDCITRLIHL NKIDPHAPNE MLYGRIGYIY ALLFVNKNFG VEKIPQSHIQ
   181  QICETILTSG ENLARKRNFT AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVSQGKL
   241  HSLVKPSVDY VCQLKFPSGN YPPCIGDNRD LLVHWCHGAP GVIYMLIQAY KVFREEKYLC
   301  DAYQCADVIW QYGLLKKGYG LCHGSAGNAY AFLTLYNLTQ DMKYLYRACK FAEWCLEYGE
   361  HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KARFPAFEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LANCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.2

Highest tissue expression

162 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

-0.74

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate metabolic process
• cellular detoxification
• G protein-coupled receptor signaling pathway
• peptide modification

Molecular functions

• G protein-coupled receptor activity
• glutathione binding
• glutathione transferase activity
• low-density lipoprotein particle receptor binding
• SH3 domain binding
• zinc ion binding

Cellular components

• cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Lanthionine synthetase C-like
• Six-hairpin glycosidase-like superfamily
• LanC-like protein, eukaryotic
• Lanthionine synthetase C-like protein

KeywordsUniProt

• Acetylation
• Cell membrane
• Cytoplasm
• Membrane
• Metal-binding
• Transferase
• Zinc

InteractionsUniProt · HPA

Protein binding partners of LANCL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EPS8
• STOM
• ALDH16A1
• CAPZB