Seroatlas · Human Serome Atlas

DERA

Deoxyribose-phosphate aldolase

Also known as: CGI-26, DEOC, DEOC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y315
Gene
DERA
Ensembl
ENSG00000023697
Chromosome
12
Canonical length
318 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables deoxyribose-phosphate aldolase activity. Involved in deoxyribonucleoside catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q9Y315|DERA
     1  MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS
    61  GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI
   121  PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK
   181  ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI
   241  RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ
   301  IYHHVTGRYA AYHDLPMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DERA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • liver: 98 nTPM
  • kidney: 69 nTPM
  • small intestine: 51 nTPM
  • rectum: 40 nTPM
  • duodenum: 39 nTPM
  • colon: 37 nTPM

Single-cell type

  • platelets: 463 nCPM
  • enterocytes: 220 nCPM
  • esophageal apical cells: 213 nCPM
  • melanocytes: 201 nCPM
  • cone photoreceptor cells: 178 nCPM
  • endometrial glandular cells: 167 nCPM

Immune cell

  • non-classical monocyte: 77 nTPM
  • myeloid DC: 75 nTPM
  • intermediate monocyte: 69 nTPM
  • classical monocyte: 59 nTPM
  • NK-cell: 46 nTPM
  • total PBMC: 42 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • medulla oblongata: 19 nTPM
  • white matter: 19 nTPM
  • hypothalamus: 18 nTPM
  • cerebellum: 17 nTPM
  • basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • deoxyribose-phosphate aldolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DERA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DERA as an antibody target. Whether an autoantibody or antibody against DERA could matter depends on whether native DERA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DERA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DERA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DERA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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