Seroatlas · Human Serome Atlas

ABLIM3

Actin-binding LIM protein 3

Also known as: ABLM3_HUMAN, KIAA0843

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94929
Gene: ABLIM3
Ensembl: ENSG00000173210
Chromosome: 5
Canonical length: 683 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>O94929|ABLIM3
     1  MNTSIPYQQN PYNPRGSSNV IQCYRCGDTC KGEVVRVHNN HFHIRCFTCQ VCGCGLAQSG
    61  FFFKNQEYIC TQDYQQLYGT RCDSCRDFIT GEVISALGRT YHPKCFVCSL CRKPFPIGDK
   121  VTFSGKECVC QTCSQSMASS KPIKIRGPSH CAGCKEEIKH GQSLLALDKQ WHVSCFKCQT
   181  CSVILTGEYI SKDGVPYCES DYHAQFGIKC ETCDRYISGR VLEAGGKHYH PTCARCVRCH
   241  QMFTEGEEMY LTGSEVWHPI CKQAARAEKK LKHRRTSETS ISPPGSSIGS PNRVICAKVD
   301  NEILNYKDLA ALPKVKSIYE VQRPDLISYE PHSRYMSDEM LERCGYGESL GTLSPYSQDI
   361  YENLDLRQRR ASSPGYIDSP TYSRQGMSPT FSRSPHHYYR SGPESGRSSP YHSQLDVRSS
   421  TPTSYQAPKH FHIPAGDSNI YRKPPIYKRH GDLSTATKSK TSEDISQTSK YSPIYSPDPY
   481  YASESEYWTY HGSPKVPRAR RFSSGGEEDD FDRSMHKLQS GIGRLILKEE MKARSSSYAD
   541  PWTPPRSSTS SREALHTAGY EMSLNGSPRS HYLADSDPLI SKSASLPAYR RNGLHRTPSA
   601  DLFHYDSMNA VNWGMREYKI YPYELLLVTT RGRNRLPKDV DRTRLERHLS QEEFYQVFGM
   661  TISEFDRLAL WKRNELKKQA RLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABLIM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

liver: 110 nTPM
heart muscle: 82 nTPM
adipose tissue: 65 nTPM
cerebellum: 61 nTPM
breast: 57 nTPM
parathyroid gland: 56 nTPM

Single-cell type

esophageal apical cells: 827 nCPM
rod photoreceptor cells: 790 nCPM
hepatocytes: 340 nCPM
vascular endothelial cells: 186 nCPM
platelets: 162 nCPM
urothelial cells: 144 nCPM

Immune cell

total PBMC: 2.7 nTPM
neutrophil: 0.9 nTPM
plasmacytoid DC: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 99 nTPM
medulla oblongata: 74 nTPM
spinal cord: 68 nTPM
hypothalamus: 58 nTPM
white matter: 58 nTPM
pons: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABLIM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ABRA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABLIM3 as an antibody target. Whether an autoantibody or antibody against ABLIM3 could matter depends on whether native ABLIM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABLIM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABLIM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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