Seroatlas · Human Serome Atlas

ABLIM2

Actin-binding LIM protein 2

Also known as: ABLM2_HUMAN, KIAA1808

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6H8Q1
Gene: ABLIM2
Ensembl: ENSG00000163995
Chromosome: 4
Canonical length: 611 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>Q6H8Q1|ABLIM2
     1  MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG
    61  GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD
   121  RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC
   181  KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR
   241  CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY
   301  AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC
   361  RTSSPSSTGS VSLGRYTPTS RSPQHYSRPG SESGRSTPSL SVLSDSKPPP STYQQAPRHF
   421  HVPDTGVKDN IYRKPPIYRQ HAARRSDGED GSLDQDNRKK SSWLMLKGDA DTRTNSPDLD
   481  TQSLSHSSGT DRDPLQRMAG DSFHSRFPYS KSDPLPGHGK NGLDQRNANL APCGADPDAS
   541  WGMREYKIYP YDSLIVTNRI RVKLPKDVDR TRLERHLSPE EFQEVFGMSI EEFDRLALWK
   601  RNDLKKKALL F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABLIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 188 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 188 nTPM
tongue: 69 nTPM
basal ganglia: 30 nTPM
cerebral cortex: 24 nTPM
spleen: 19 nTPM
esophagus: 12 nTPM

Single-cell type

thymic myoid cells: 1,250 nCPM
podocytes: 1,220 nCPM
myonuclei: 668 nCPM
esophageal apical cells: 291 nCPM
retinal horizontal cells: 256 nCPM
retinal ganglion cells: 213 nCPM

Immune cell

MAIT T-cell: 0.7 nTPM
memory CD4 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM
gdT-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 83 nTPM
basal ganglia: 81 nTPM
hypothalamus: 77 nTPM
amygdala: 59 nTPM
white matter: 53 nTPM
pons: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABLIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ABRA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABLIM2 as an antibody target. Whether an autoantibody or antibody against ABLIM2 could matter depends on whether native ABLIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABLIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABLIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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