ABI3BP

Protein identityUniProt · HPA

UniProt accession

Q7Z7G0

Gene

ABI3BP

Ensembl

ENSG00000154175

Chromosome

3

Canonical length

1068 aa

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including extracellular matrix organization; positive regulation of cell-substrate adhesion; and regulation of postsynapse organization. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1068 residues, UniProt reviewed canonical sequence.

>Q7Z7G0|ABI3BP
     1  MLSSLGCLLL CGSITLALGN AQKLPKGKRP NLKVHINTTS DSILLKFLRP SPNVKLEGLL
    61  LGYGSNVSPN QYFPLPAEGK FTEAIVDAEP KYLIVVRPAP PPSQKKSCSG KTRSRKPLQL
   121  VVGTLTPSSV FLSWGFLINP HHDWTLPSHC PNDRFYTIRY REKDKEKKWI FQICPATETI
   181  VENLKPNTVY EFGVKDNVEG GIWSKIFNHK TVVGSKKVNG KIQSTYDQDH TVPAYVPRKL
   241  IPITIIKQVI QNVTHKDSAK SPEKAPLGGV ILVHLIIPGL NETTVKLPAS LMFEISDALK
   301  TQLAKNETLA LPAESKTPEV EKISARPTTV TPETVPRSTK PTTSSALDVS ETTLASSEKP
   361  WIVPTAKISE DSKVLQPQTA TYDVFSSPTT SDEPEISDSY TATSDRILDS IPPKTSRTLE
   421  QPRATLAPSE TPFVPQKLEI FTSPEMQPTT PAPQQTTSIP STPKRRPRPK PPRTKPERTT
   481  SAGTITPKIS KSPEPTWTTP APGKTQFISL KPKIPLSPEV THTKPAPKQT PRAPPKPKTS
   541  PRPRIPQTQP VPKVPQRVTA KPKTSPSPEV SYTTPAPKDV LLPHKPYPEV SQSEPAPLET
   601  RGIPFIPMIS PSPSQEELQT TLEETDQSTQ EPFTTKIPRT TELAKTTQAP HRFYTTVRPR
   661  TSDKPHIRPG VKQAPRPSGA DRNVSVDSTH PTKKPGTRRP PLPPRPTHPR RKPLPPNNVT
   721  GKPGSAGIIS SGPITTPPLR STPRPTGTPL ERIETDIKQP TVPASGEELE NITDFSSSPT
   781  RETDPLGKPR FKGPHVRYIQ KPDNSPCSIT DSVKRFPKEE ATEGNATSPP QNPPTNLTVV
   841  TVEGCPSFVI LDWEKPLNDT VTEYEVISRE NGSFSGKNKS IQMTNQTFST VENLKPNTSY
   901  EFQVKPKNPL GEGPVSNTVA FSTESADPRV SEPVSAGRDA IWTERPFNSD SYSECKGKQY
   961  VKRTWYKKFV GVQLCNSLRY KIYLSDSLTG KFYNIGDQRG HGEDHCQFVD SFLDGRTGQQ
  1021  LTSDQLPIKE GYFRAVRQEP VQFGEIGGHT QINYVQWYEC GTTIPGKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABI3BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

92 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.56

gnomAD pLI

0

gnomAD missense Z

0.83

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• extracellular matrix organization
• positive regulation of cell-substrate adhesion

Cellular components

• extracellular matrix
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Fibronectin type III
• Immunoglobulin-like fold
• Fibronectin type III superfamily
• Target of Nesh-SH3/FNDC1, C-terminal domain
• Fibronectin type III domain
• Target of Nesh-SH3 C-terminal domain

KeywordsUniProt

• Glycoprotein
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of ABI3BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ABI3