ABC transporter family G domain

Definition

This domain is found in several ATP binding cassette transporters family G (ABCG). ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which uses the hydrolysis of ATP to energise diverse biological import and export systems. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two different ones (mostly bacterial importers) PMID:9873074. The function of the integral inner-membrane protein is to translocate the substrate across the membrane and seems to play an important role in substrate recognition PMID:10331089. ABC family G is a multidrug ATP-binding cassette transporter expressed in the plasma membranes of several tissues that is involved in endogenous substrates translocation, modifies drug pharmacokinetics and acts as a protector against xenobiotics PMID:30405239.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• ABCG1
• ABCG2
• ABCG4
• ABCG5
• ABCG8