MUC5AC

Protein identityUniProt · HPA

UniProt accession

P98088

Gene

MUC5AC

Ensembl

ENSG00000215182

Chromosome

11

Canonical length

5654 aa

Protein class

Predicted secreted proteins

Subcellular location

Vesicles

Secretome location

Secreted to digestive system

Quaternary structure

Homomultimer

OverviewNCBI Gene

Predicted to enable extracellular matrix constituent, lubricant activity. Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within maintenance of lens transparency. Located in extracellular space and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple). [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

5654 residues, UniProt reviewed canonical sequence.

>P98088|MUC5AC
     1  MSVGRRKLAL LWALALALAC TRHTGHAQDG SSESSYKHHP ALSPIARGPS GVPLRGATVF
    61  PSLRTIPVVR ASNPAHNGRV CSTWGSFHYK TFDGDVFRFP GLCNYVFSEH CGAAYEDFNI
   121  QLRRSQESAA PTLSRVLMKV DGVVIQLTKG SVLVNGHPVL LPFSQSGVLI QQSSSYTKVE
   181  ARLGLVLMWN HDDSLLLELD TKYANKTCGL CGDFNGMPVV SELLSHNTKL TPMEFGNLQK
   241  MDDPTDQCQD PVPEPPRNCS TGFGICEELL HGQLFSGCVA LVDVGSYLEA CRQDLCFCED
   301  TDLLSCVCHT LAEYSRQCTH AGGLPQDWRG PDFCPQKCPN NMQYHECRSP CADTCSNQEH
   361  SRACEDHCVA GCFCPEGTVL DDIGQTGCVP VSKCACVYNG AAYAPGATYS TDCTNCTCSG
   421  GRWSCQEVPC PGTCSVLGGA HFSTFDGKQY TVHGDCSYVL TKPCDSSAFT VLAELRRCGL
   481  TDSETCLKSV TLSLDGAQTV VVIKASGEVF LNQIYTQLPI SAANVTIFRP STFFIIAQTS
   541  LGLQLNLQLV PTMQLFMQLA PKLRGQTCGL CGNFNSIQAD DFRTLSGVVE ATAAAFFNTF
   601  KTQAACPNIR NSFEDPCSLS VENEKYAQHW CSQLTDADGP FGRCHAAVKP GTYYSNCMFD
   661  TCNCERSEDC LCAALSSYVH ACAAKGVQLG GWRDGVCTKP MTTCPKSMTY HYHVSTCQPT
   721  CRSLSEGDIT CSVGFIPVDG CICPKGTFLD DTGKCVQASN CPCYHRGSMI PNGESVHDSG
   781  AICTCTHGKL SCIGGQAPAP VCAAPMVFFD CRNATPGDTG AGCQKSCHTL DMTCYSPQCV
   841  PGCVCPDGLV ADGEGGCITA EDCPCVHNEA SYRAGQTIRV GCNTCTCDSR MWRCTDDPCL
   901  ATCAVYGDGH YLTFDGQSYS FNGDCEYTLV QNHCGGKDST QDSFRVVTEN VPCGTTGTTC
   961  SKAIKIFLGG FELKLSHGKV EVIGTDESQE VPYTIRQMGI YLVVDTDIGL VLLWDKKTSI
  1021  FINLSPEFKG RVCGLCGNFD DIAVNDFATR SRSVVGDVLE FGNSWKLSPS CPDALAPKDP
  1081  CTANPFRKSW AQKQCSILHG PTFAACHAHV EPARYYEACV NDACACDSGG DCECFCTAVA
  1141  AYAQACHEVG LCVSWRTPSI CPLFCDYYNP EGQCEWHYQP CGVPCLRTCR NPRGDCLRDV
  1201  RGLEGCYPKC PPEAPIFDED KMQCVATCPT PPLPPRCHVH GKSYRPGAVV PSDKNCQSCL
  1261  CTERGVECTY KAEACVCTYN GQRFHPGDVI YHTTDGTGGC ISARCGANGT IERRVYPCSP
  1321  TTPVPPTTFS FSTPPLVVSS THTPSNGPSS AHTGPPSSAW PTTAGTSPRT RLPTASASLP
  1381  PVCGEKCLWS PWMDVSRPGR GTDSGDFDTL ENLRAHGYRV CESPRSVECR AEDAPGVPLR
  1441  ALGQRVQCSP DVGLTCRNRE QASGLCYNYQ IRVQCCTPLP CSTSSSPAQT TPPTTSKTTE
  1501  TRASGSSAPS STPGTVSLST ARTTPAPGTA TSVKKTFSTP SPPPVPATST SSMSTTAPGT
  1561  SVVSSKPTPT EPSTSSCLQE LCTWTEWIDG SYPAPGINGG DFDTFQNLRD EGYTFCESPR
  1621  SVQCRAESFP NTPLADLGQD VICSHTEGLI CLNKNQLPPI CYNYEIRIQC CETVNVCRDI
  1681  TRLPKTVATT RPTPHPTGAQ TQTTFTTHMP SASTEQPTAT SRGGPTATSV TQGTHTTLVT
  1741  RNCHPRCTWT KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL QCRAKSHPEV
  1801  SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPRGCHMT STPGSTSSSP
  1861  AQTTPSTTSK TTETQASGSS APSSTPGTVS LSTARTTPAP GTATSVKKTF STPSPPPVPA
  1921  TSTSSMSTTA PGTSVVSSKP TPTEPSTSSC LQELCTWTEW IDGSYPAPGI NGGDFDTFQN
  1981  LRDEGYTFCE SPRSVQCRAE SFPNTPLADL GQDVICSHTE GLICLNKNQL PPICYNYEIR
  2041  IQCCETVNVC RDITRPPKTV ATTRPTPHPT GAQTQTTFTT HMPSASTEQP TATSRGGPTA
  2101  TSVTQGTHTT PVTRNCHPRC TWTTWFDVDF PSPGPHGGDK ETYNNIIRSG EKICRRPEEI
  2161  TRLQCRAKSH PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP FKMCLNYEVR VLCCETPKGC
  2221  PVTSTPVTAP STPSGRATSP TQSTSSWQKS RTTTLVTTST TSTPQTSTTY AHTTSTTSAP
  2281  TARTTSAPTT RTTSASPAST TSGPGNTPSP VPTTSTISAP TTSITSAPTT STTSAPTSST
  2341  TSGPGTTPSP VPTTSITSAP TTSTTSAPTT STTSARTSST TSATTTSRIS GPETTPSPVP
  2401  TTSTTSATTT STTSAPTTST TSAPTSSTTS SPQTSTTSAP TTSTTSGPGT TPSPVPTTST
  2461  TSAPTTRTTS APKSSTTSAA TTSTTSGPET TPRPVPTTST TSSPTTSTTS APTTSTTSAS
  2521  TTSTTSGAGT TPSPVPTTST TSAPTTSTTS APISSTTSAT TTSTTSGPGT TPSPVPTTST
  2581  TSAPTTSTTS GPGTTPSAVP TTSITSAPTT STNSAPISST TSATTTSRIS GPETTPSPVP
  2641  TASTTSASTT STTSGPGTTP SPVPTTSTIS VPTTSTTSAS TTSTTSASTT STTSGPGTTP
  2701  SPVPTTSTTS APTTSTTSAP TTSTISAPTT STTSATTTST TSAPTPRRTS APTTSTISAS
  2761  TTSTTSATTT STTSATTTST ISAPTTSTTL SPTTSTTSTT ITSTTSAPIS STTSTPQTST
  2821  TSAPTTSTTS GPGTTSSPVP TTSTTSAPTT STTSAPTTRT TSVPTSSTTS TATTSTTSGP
  2881  GTTPSPVPTT STTSAPTTRT TSAPTTSTTS APTTSTTSAP TSSTTSATTT STISVPTTST
  2941  TSVPGTTPSP VPTTSTISVP TTSTTSASTT STTSGPGTTP SPVPTTSTTS APTTSTTSAP
  3001  TTSTISAPTT STPSAPTTST TLAPTTSTTS APTTSTTSTP TSSTTSSPQT STTSASTTSI
  3061  TSGPGTTPSP VPTTSTTSAP TTSTTSAATT STISAPTTST TSAPTTSTTS ASTASKTSGL
  3121  GTTPSPIPTT STTSPPTTST TSASTASKTS GPGTTPSPVP TTSTIFAPRT STTSASTTST
  3181  TPGPGTTPSP VPTTSTASVS KTSTSHVSIS KTTHSQPVTR DCHLRCTWTK WFDIDFPSPG
  3241  PHGGDKETYN NIIRSGEKIC RRPEEITRLQ CRAESHPEVS IEHLGQVVQC SREEGLVCRN
  3301  QDQQGPFKMC LNYEVRVLCC ETPKGCPVTS TPVTAPSTPS GRATSPTQST SSWQKSRTTT
  3361  LVTTSTTSTP QTSTTSAPTT STTSAPTTST TSAPTTSTTS TPQTSISSAP TSSTTSAPTS
  3421  STISARTTSI ISAPTTSTTS SPTTSTTSAT TTSTTSAPTS STTSTPQTSK TSAATSSTTS
  3481  GSGTTPSPVT TTSTASVSKT STSHVSVSKT THSQPVTRDC HPRCTWTKWF DVDFPSPGPH
  3541  GGDKETYNNI IRSGEKICRR PEEITRLQCR AKSHPEVSIE HLGQVVQCSR EEGLVCRNQD
  3601  QQGPFKMCLN YEVRVLCCET PKGCPVTSTS VTAPSTPSGR ATSPTQSTSS WQKSRTTTLV
  3661  TSSITSTTQT STTSAPTTST TPASIPSTTS APTTSTTSAP TTSTTSAPTT STTSTPQTTT
  3721  SSAPTSSTTS APTTSTISAP TTSTISAPTT STTSAPTAST TSAPTSTSSA PTTNTTSAPT
  3781  TSTTSAPITS TISAPTTSTT STPQTSTISS PTTSTTSTPQ TSTTSSPTTS TTSAPTTSTT
  3841  SAPTTSTTST PQTSISSAPT SSTTSAPTAS TISAPTTSTT SFHTTSTTSP PTSSTSSTPQ
  3901  TSKTSAATSS TTSGSGTTPS PVPTTSTASV SKTSTSHVSV SKTTHSQPVT RDCHPRCTWT
  3961  KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL QCRAESHPEV SIEHLGQVVQ
  4021  CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPKGCPVT STPVTAPSTP SGRATSPTQS
  4081  TSSWQKSRTT TLVTTSTTST PQTSTTSAPT TSTIPASTPS TTSAPTTSTT SAPTTSTTSA
  4141  PTHRTTSGPT TSTTLAPTTS TTSAPTTSTN SAPTTSTISA STTSTISAPT TSTISSPTSS
  4201  TTSTPQTSKT SAATSSTTSG SGTTPSPVPT TSTTSASTTS TTSAPTTSTT SGPGTTPSPV
  4261  PSTSTTSAAT TSTTSAPTTR TTSAPTSSMT SGPGTTPSPV PTTSTTSAPT TSTTSGPGTT
  4321  PSPVPTTSTT SAPITSTTSG PGSTPSPVPT TSTTSAPTTS TTSASTASTT SGPGTTPSPV
  4381  PTTSTTSAPT TRTTSASTAS TTSGPGSTPS PVPTTSTTSA PTTRTTPAST ASTTSGPGTT
  4441  PSPVPTTSTT SASTTSTISL PTTSTTSAPI TSMTSGPGTT PSPVPTTSTT SAPTTSTTSA
  4501  STASTTSGPG TTPSPVPTTS TTSAPTTSTT SASTASTTSG PGTSLSPVPT TSTTSAPTTS
  4561  TTSGPGTTPS PVPTTSTTSA PTTSTTSGPG TTPSPVPTTS TTPVSKTSTS HLSVSKTTHS
  4621  QPVTSDCHPL CAWTKWFDVD FPSPGPHGGD KETYNNIIRS GEKICRRPEE ITRLQCRAES
  4681  HPEVNIEHLG QVVQCSREEG LVCRNQDQQG PFKMCLNYEV RVLCCETPRG CPVTSVTPYG
  4741  TSPTNALYPS LSTSMVSASV ASTSVASSSV ASSSVAYSTQ TCFCNVADRL YPAGSTIYRH
  4801  RDLAGHCYYA LCSQDCQVVR GVDSDCPSTT LPPAPATSPS ISTSEPVTEL GCPNAVPPRK
  4861  KGETWATPNC SEATCEGNNV ISLRPRTCPR VEKPTCANGY PAVKVADQDG CCHHYQCQCV
  4921  CSGWGDPHYI TFDGTYYTFL DNCTYVLVQQ IVPVYGHFRV LVDNYFCGAE DGLSCPRSII
  4981  LEYHQDRVVL TRKPVHGVMT NEIIFNNKVV SPGFRKNGIV VSRIGVKMYA TIPELGVQVM
  5041  FSGLIFSVEV PFSKFANNTE GQCGTCTNDR KDECRTPRGT VVASCSEMSG LWNVSIPDQP
  5101  ACHRPHPTPT TVGPTTVGST TVGPTTVGST TVGPTTPPAP CLPSPICQLI LSKVFEPCHT
  5161  VIPPLLFYEG CVFDRCHMTD LDVVCSSLEL YAALCASHDI CIDWRGRTGH MCPFTCPADK
  5221  VYQPCGPSNP SYCYGNDSAS LGALPEAGPI TEGCFCPEGM TLFSTSAQVC VPTGCPRCLG
  5281  PHGEPVKVGH TVGMDCQECT CEAATWTLTC RPKLCPLPPA CPLPGFVPVP AAPQAGQCCP
  5341  QYSCACNTSR CPAPVGCPEG ARAIPTYQEG ACCPVQNCSW TVCSINGTLY QPGAVVSSSL
  5401  CETCRCELPG GPPSDAFVVS CETQICNTHC PVGFEYQEQS GQCCGTCVQV ACVTNTSKSP
  5461  AHLFYPGETW SDAGNHCVTH QCEKHQDGLV VVTTKKACPP LSCSLDEARM SKDGCCRFCP
  5521  PPPPPYQNQS TCAVYHRSLI IQQQGCSSSE PVRLAYCRGN CGDSSSMYSL EGNTVEHRCQ
  5581  CCQELRTSLR NVTLHCTDGS SRAFSYTEVE ECGCMGRRCP APGDTQHSEE AEPEPSQEAE
  5641  SGSWERGVPV SPMH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC5AC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

175 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MUC5AC.

Disease | ImmuneIEDB

Conditions an epitope on MUC5AC was assayed in.

• melanoma T cell
• cholangiocarcinoma T cell

ReferencesPubMed · IEDB

Publications for MUC5AC from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.84

gnomAD pLI

0

gnomAD missense Z

1.26

OntologyGO

Molecular functions

• extracellular matrix structural constituent
• metal ion binding

Cellular components

• extracellular exosome
• extracellular matrix
• extracellular space
• Golgi lumen
• mucus layer
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• VWFC domain
• von Willebrand factor, type D domain
• Trypsin Inhibitor-like, cysteine rich domain
• Cystine knot, C-terminal
• VWF/SSPO/Zonadhesin-like, cysteine-rich domain
• WxxW domain
• Serine protease inhibitor-like superfamily
• Mucin/von Willebrand/Thrombospondin superfamily
• Otogelin-like/Mucin, TIL domain
• von Willebrand factor type D domain
• Trypsin Inhibitor like cysteine rich domain
• C8 domain
• Mucin-2 protein WxxW repeating region
• Otogelin-like/Mucin TIL domain

KeywordsUniProt

• Copper
• Disulfide bond
• Glycoprotein
• Metal-binding
• Repeat
• Secreted
• Signal