Seroatlas · Human Serome Atlas

MUC19

Mucin-19

Also known as: MUC19_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5P9
Gene: MUC19
Canonical length: 8384 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MUC19 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

8384 residues, UniProt reviewed canonical sequence.

>Q7Z5P9|MUC19
     1  MKLILWYLVV ALWCFFKDVE ALLYRQKSDG KIAASRSGGF SYGSSSSGDL DRKKPLFSLE
    61  FGSPGETEDK SRQRQDAGSP KSEDTPAGGF FNSSSSSGDS DRTKPFFSLG LGAPGKAEDK
   121  SGDSQDAGGS KSEDTPPGGF FYGSSSSGDS DKKKPLFSFE FGATGEDEDK SRERWDAGNS
   181  RSEDSPADST NTRYGAGFSS SGASLDVGFG WGISDEKGLE VSKADGRETR GSGSAGGETI
   241  VFGPDAGSSV GTGSSGLKLG AGKGDAAFGF EVSDSNSFGD TGISSKTVEG NQTSSSGGSV
   301  SIDLGDTSFR SENQFVGGGS LNSISNLWDS GQEGFGINEI GGNGMSGSVS AEAGFKGFGS
   361  DSSSSGDSSA RNGFENSSGI SEDSGVILGS SDQHEVELSR TGGNRKRSSD PDEAGNLSPG
   421  SDVSDSGGNT WSSDSGSGGG GVTSSSEYST SGPLNTPEKG SHIPEATPKY SETNAIIGEI
   481  STWSKGAYKS FNGRIFFFES SCPYTFCRHC IESGGDFNIE IKRNNDSEIE KITVLIDNND
   541  VSIFGDTILV NGESVQIPYN NKLIHIKKYG EHNVLNSRRG ILTLMWDKNN KLSLTLHKQY
   601  PTCGLCGNFN STPGQDINEH IANSKIPGDC PNAVGKSYEV CEDGIQHCNK IIGTYFEKCG
   661  KVAALSNDYK MICIDEYCQT RDKTSTCDTY SELSRLCASD GPGTFESWRS DSDVVCGTQR
   721  CPEQHIYKEC GPSNPATCSN VAPFQDSECV SGCTCPEGYL LDDIGEKGKC VLKAECPCES
   781  SGTVYQPGEV REGPCGSQCT CQDAKWSCTE ALCPGRCKVE GSSLTTFDGV KYNFPGNCHF
   841  LAVHNEDWSI SVELRPCPSG QTGTCLNSVT LLLNSSVPVD KYVFNSDGTV TNDKIRNQGY
   901  YYSDKIQIFN ASSSYLQVET YFHVKLQIQI VPVMQLYVSM PPNQFTDTVG LCGSYNNKAE
   961  DDFMSSQNIL EKTSQAFANS WEMMSCPKGN PSSCISIEKE KFAERHCGIL LDSSGPLASC
  1021  HPIVNPKPYH EECKKYTCTC ENSQDCLCTI LGNYVKACAE KETYIVGWRT GLCEHSCPSG
  1081  LVFKYNVKAC NSSCRSLSER DRSCDVEDVP VDGCTCPDAM YQNNEGNCVL KSQCDCYIND
  1141  EVMQPGKLIH IDDNKCVCRD GILLCQIPID LTLQNCSGGA EYVDCSDPKA QRRTNRTCST
  1201  RNIPVFDENL PCKRGCFCPE GMVRNSKGIC VFPNDCPCSF GGREYDEGSV TSVGCNECTC
  1261  IKGSWSCTQN ECQTICHIYG EGHVRTFDGK SYSFDGLCQY SFLEDYCGHE NGTFRILTES
  1321  VPCCEDGLTC SRKIIVAFQD QNIVLQDGKV TAVKSTESKK CELNANAYSI HTVGLYLILK
  1381  FQNGIIVIWD KNTRLSVILD PNWNGKVCGL CGNNNGDLKD DFTTRYSSVA SGALEFGNSW
  1441  KTSQECSDTV AQTFPCDSNP YCKAWAVRKC EILRDSTFRD CHNKVDPSAY HDACIEEACA
  1501  CDMEGKYLGF CTAVAMYAEA CSAVGVCVSW RKPNLCPVYC DYYNAPGECR WHYEPCGTVT
  1561  AKTCKDQLVG QKFSSLLEGC YAKCPDSAPY LDENTMKCVS LSECSCFYND VIPAGGVIED
  1621  NCGRTCYCIA GQLECSETAP TNSTFAVSTT TATTILSTGA AITLVTGGPS TAASIPAITT
  1681  SSSETTGTTL GPLTEPFTTG ITETSVPIIS TSGNAGMTGV VSPTVTGASG MAGTTGGVDA
  1741  ATTGAASENT SERAGTPRVS GETPAVGGGS TPGEAGPGAT VSGSTGVSAG SITASPGASA
  1801  TSSESSKSGT TGPSVGGKTG ATSSEATSSE GMSGVTGQSL GSTAGSDSEI TAKTSFTGSS
  1861  PPGKLTRPSP GSPGHFSGGT TEWGNVATTG AAGENTSGAL GSTEGSVEAT TSAGSGNTAG
  1921  TSGTGDTGPG NTAVSGTPVV SPGATPGAPG SSTPGEADIG NTSFGKSGTP TVSAASTTSS
  1981  PVSKHTDAAS ATAVTISGSK PGTPGTPGGA TSGGKITSGW SSSGTSTGAS NTPGATGSST
  2041  GQTDTSGPSA KVTGNYGQSS EIPGTIKSSS DVSGTMGQSD TTSGPSVAVT RTSEQSSGVT
  2101  VASEPSVGVS GTTGPLAEIS GTTRPLVSGL RTTGSSAEGS GTTGPSSRES VTTRPLAEGS
  2161  GTSGQSVTGS RATGLSATEL GTTVSFTGGL GTSRSSARET RTTGPSADGS GTTGPSVVRS
  2221  GTTRLSVGVT RATESSPGVT GTTTPSAEES RTTGPSVLVT GTTGQSGQGS GTTGKSFIES
  2281  GPSVVGSGTT GPTSAGLGTT APSTRRSSTT KPSVGRTGTT GQSGAESGTT EPSARVAGVT
  2341  GTSAEVSGRI EPSATESSTS RPLGETTGTT IPSMEGSEAT GPSVIGSETT RLSVIGSGTT
  2401  GTSSGGSGAT RSSGGGMGTT GQSTARSETT GPLFGLTGTF GQSATVTGTS SNSAGVTTPE
  2461  KSPGVAMTTG LLVEGSATTQ PRILESETTE SSAGVIVTSG QSARVTGATG PSAGETGTTE
  2521  PSTEGSVAAV LFVIGSETTR PLDIGSGTTG TLSGGSSTTR SSDGTTGTTR KSTARSETTG
  2581  LSGLTGTSGQ LAGVTGTSSK SAGVTVTSEK SAGVAVITGS FVERPVTTGP PLLESETTRP
  2641  SGGVTVTSGQ SARVTETVGA SAGVTGTTGP STEGSGATGP SVVGSGTTRP LAGESGTTES
  2701  SAGVTGTRPS SSRESATTGP SDEGSGTTGL SAGVTVTSGQ SVRKTGTTGA PAGVTETTRP
  2761  SVVKSGTTGP SVIGTRTTGT SSGGSGATRS SGGETETTGQ SAVKSGTTES FTRLTRTSGQ
  2821  SAGMTGTSAQ SAGVALTSPF VEGLVTTGSS TVGLETTRPS AVGSGKTGPP VVKAQTTGPS
  2881  AGVTVTSGQS ARMTGASGPS VGVTGTTGPA SKGLGTIRPS VVGLETTELS AEGSGTTGPP
  2941  IVGETTVPSA GVTVTSGYSD RVTGATEPLA GVTGTIKPSV AGSVTTGPSV TGVETTAKTT
  3001  SGGLSTTISS VGGTGTTGQS PERSGTTGPF TGLTGTSAQS AGVTMTSIQS AGVLVTTGLN
  3061  VDGLGTTGKA LIGSGTTGLS AEATGTIGPS TEGLEKTGPS ITGSGTTRPL VTESWTAGTS
  3121  SGGHSTTSPS VRGTETTGQS AAESVTTGPV TGYTETSGPS AGVTVTPRQS PTVTQTTGSS
  3181  AAVSGTTVQS LTVSGTTRPS SGQTEITGSS VKESGTTESS AVRSGTTGPT AGVTGTNGPS
  3241  SAGVTGITGS SPGVTGTTGS SPGVTGTTGS SARSGTSIPS VGKTGTTRTS VEESRTTRPS
  3301  AGITGTNGLS AEVTGTTGPL AGVTGTTGPS AGVTRTTGLS AGETGTTGLS PGVTRTTRSS
  3361  AGLTGKTGLS AGVTGKTGLS AEVTGTTRLS AGVTGTTGPS PGVTGTTGTP AGVTGTTELS
  3421  AGVTGKTGLS SEVTETTGLS YGVKRTIGLS AGSTGTSGQS AGVAGTTTLS AEVTGTTRPS
  3481  AGVTGTTGLS AEVTEITGIS AVVTGTTGPS AGVTETTGSS AGVAGTTRLS AGVTGITGLS
  3541  AGVTGTTGLS TEVTGTTGPS AGATGTTGLS VGVTGITGLS DVVTETTGSS ARSGTGIPSV
  3601  GETRTTSTSV EESRTTRPSA GIMGTNGLPA EVTGTTEPLA GGTGTTGILA GVTGTTGLSA
  3661  GETGKIGSSA GVTGKTGSSA RVTGKTGPSA EVTGKTGLSA GVTGTTGLSP GVTGTSGLSA
  3721  EVTGTTGPSA EATGLPGVSA GVTGTTGSLA GGTGTIGLSA GVTGTTGSSA GVTGTTGLSA
  3781  GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA GVTGTTGLSA
  3841  GVTETIRLSA GVTGTIRSSA GVTGITGLSA GVTGTTGPSA GVTGSTGLLA GVTETTGQSA
  3901  KVTGTTGQSV GVTGTTRSSG GVTGITGLSA GVTGTNGLSA VTGMTGLSAE VTGTTGLSVG
  3961  VTGIAGLSAG VTGITGPSAG ITGTTTISAG VTGTSGLSAE ATGITGLSAG VTGKTGLSAG
  4021  VTETIGLSAE ATGTIGSSPG VTGTTGSSTG VTGITGLSAG VTGTTGLSTE VTGTTGPSAG
  4081  VTRTTGLSAG VTGITGLSAI VTETTGSSAR SGTSIPSVGE TGTTRTSVEE SRTTRPSAGI
  4141  TGTNGLSAEV TGTIGPLAGG TGTTGLSAGV TGTVGSSAVV TGTTGLSAGV TGTTGPSAEE
  4201  TGATGPSAEV TETTGPSAGV TGTGRLSAEV TGTTGPSAEV TGLPGESAEV TGTIGSPAGV
  4261  TGTTQLSAVV TGITGLSAEV TGTTGLSAGV TGITGLSAEV TRTTGLSAGV TGTIGLSAGV
  4321  TGTTRPSAGV TGTTGQSAEV TGTTEPSAGL TETTGSSTGV TGATGPLAGV TGTTGISTEV
  4381  TGTTGPSARV TGTTVLSAGV TGITGLSAIV TETTGSSARS GTSTPSVGET GTTRTSVEES
  4441  RATRPSAGIT GTNGQSAEVT WITGPLAGVT GTTGISAGVT GTTGLSAGVT GTIGSSAVVT
  4501  GINGLSAGVT GTTGPSAEET GATGPSAEVT GTTGPSAEET GATGPSAEVT GTTGPSGGVT
  4561  GTNGLSAEVT GTTGPSAEVT GLPGVSAGVT GTIGSPAAVT GTIRPSAVVT GITGLSAEVT
  4621  GTTGLSAWVT GIAGLSAGVT ETIGSSAGVT GTNGLSAEAT GTTGPSAGVT GTTGLSAGVT
  4681  GTAGLSARVT ESTGLSAGVT GTTGLSAGVT GTTGPSAGIT GTNGLSAEVT GTTGPLAGVT
  4741  GTIGLSAGVT GIAGLSAGVT ESTGLSAGVT GTIRSSAVVT GINGLSAGVT GTTGPSAEET
  4801  GATGPSAEVT GTTGPSGGVT GTSGISAEVT GTTGPSAEVT GLPGVSAGVT GTIGSPAAVT
  4861  GTTRPSAVVT GISGLSAEVT GTTGLSAGVT ETIGSSAGVT GTNGLSAEAT ETTGPSAGVT
  4921  GTTGLSAGVT GTTGPSAGIA GTNGLSAGVT GTTGLSARVT ESTGLSAGVT GTIGSSAVVT
  4981  ETTRLSSGVT GTIGPSAEET GATGLSAEVT GTTGSLAEVT GTTGLSAGVT GTIGSSAVVT
  5041  GTTGLSAGIT GTNGLSAEVT GTAGPLAGVT GTTGLSAGVT GTTGLSAGVT ETTGQSAGVT
  5101  ESTGLSPGVT GTIGSSAVVT GIKGLSAGVT GTTGPSAEET GATGPSAEVT GTTGPSGGVT
  5161  GTSVLSVEVT GTTGPSAEVT GLPGVSAGLT GTIGSPAAVR GTTWPSAVVT GISGLSGEVT
  5221  GTTGLSAGVT GIGGLSAGVT GTIGSSAGVT GTNALSAEAT GTTGPSAGVT GTTGLSAGVT
  5281  GTTGLSAGVT GTIRSSAVVT ETTGLSAGVT GTTGPSAGIA GTNGLSAEVT GTTGLSAGMT
  5341  GTTGLSARVT ESTGLSAGVT GTIGSSAVVT ETTRLSAGVT GTIGPSAEET GATGLSAEVT
  5401  RTTGSLAGVT GTTGPSAVVT GKTELSAEVT GTTELSAEVT EKTGPSAEVT GKTGLSAGVM
  5461  ETTGPSAEVT GTTGSSAGVT GTTGPSAGVT GTTGPSAEAT GLPGVSAGVT GTIGSPAGVT
  5521  GTARLSAVVT GISGLSAEVT GTTGLSTGVT GIAGHSAAVT GITRPSAGVT GTTTVSAGVT
  5581  GTIGLSAEAT GITLPSAGVT ETTGLSAGVT ETIGLSAGVT GTIGSSAGVT EITGLSAGVT
  5641  GTTGPSAGVT GSTVLSAGVT ATTGQSVGVT GTTGPSAGVT GTTGLSAGVT GIAGLSAGVT
  5701  GITGPSAGVT GTTTVSAGVT GTTGLSAEAT EITGLSAGVT GTTGLSAGVT GIAGLSAGVT
  5761  ETIGSSAGVT GTNGLSAEAT GKTGPSAGVT GTTGLSAGVT GTTGLSAGVT ETIGLSAGVT
  5821  GTIGSSAGVK GTTGQSAEVT GATGQSVGVT GTTRSSGGVT GITGLSAGLR GTTVSSAKAG
  5881  TSIPLTGKTG TTRTSVEEST TTGPSAGITG TNGLSAEMTG TNELSAGVTG TIGSSAGVTG
  5941  TTGLSVEATV TTGLSAGVTG TTVPLAGVTW TPGPSAGVTG IAALSAGVTG KSGLSAGVTG
  6001  KTGLSAGVTG TTGPSAEATG KTGLSAGVTG ITGPFAEVTG TTGLSAGVIG TTGSSAEVTG
  6061  ITGLSAGVTG KTRSSAGVTG TTGLSAKSGT SIPSAGKTGT TKTSVEESRT TRPSAGITAT
  6121  TGVPAATSPG AEGESIASTS VATGAIPRST IAPGSTTTGT TGVTTGTTLA PRSFNIGTSG
  6181  GISGKTLKPG SYVSEATTAT GTPGAGPSGG TTISSPEVST ISEVSNTGIT GVGSETSIET
  6241  GISNTATTGV APGTTLAPGS SSTEATTSIG GSASTRGGIA TEATGSTRGV RTTGSEAPEG
  6301  TSGEFSGTTI SSGGFHTEAT TLTGGRGSIG TESRAESTTS LPQSAKTRGG ILTEATSSTG
  6361  RIRATGSEAP GGTSRKFSGT TISSGGSHTE ATTLAGGRDS TESEFRTATI GVVPATTVAP
  6421  GSSKTEATTF LGVSGTTSVG RATGATTSIA GSDTSQAEHP GGTSGEFPGT TITSGDSHTE
  6481  ATALTGSRGS IGTESTVETT TYIGESGTTR GGLATATTGA FSGKTLEPGN DNTEATGSTG
  6541  GIRATRTEAP GGTSGEFPGT TFTSGGSHTE ATTFTGGKGS TGTESRAATT RAAPGTTLVP
  6601  GSSNTGATAS PGGSATTRGR ITTATTGAFS GKTLESENDN TEATSSTRGV RTTRSEAPGG
  6661  TSGEFPGTRI TSGGSYTATT RAAPGTTLAP GSSNTGATAS LGGSAMTRGR ITTATTGAFS
  6721  GKTLEPGNNN TEATSSTRGV RTTRSEAPGE ATTLTGDRSS TGSESRTATT GVAPGTTVAP
  6781  GSSKTEATTF LGVSGTTNIG RATGATTSIV GSDTSQAERP GGTTVVSPGA SSTSQSSRPG
  6841  TSVTPDSSAS ESETVTTKEF SGTTAISRTS HTGTPAASGG QATGSLTATT GVAPGTTVAP
  6901  GSSNTEATTS VGERETTKAE IITGDTGELS GTTIISENST TAGITAATGK QAGTSEVAPS
  6961  TTVAPGSFST AATTSPGASG TTGVTTTTKT TTSLGGSGTT GAEIKSATTG APGSRTGTAG
  7021  VPSATTVSPG SSNSEATTSV GESGKTGAET ITEATTSTEG TGTSGTGFKT GTSEVAPATT
  7081  VAPGSFSTAA TTSPGASGMT GVTTTTKTTT SLGGSGTTGA KIKLVGTTTT APESRTAGVP
  7141  SGTRVTPGSS NSEATTSVEE SRITRAEVIT EATTFSGGSG ATRAGLPRGT TGEFSGTNFI
  7201  SGSSNTEATT STEGTGTSGT GFKIAGITSA PGKQAGTSGV SLATTVAPGS FSTATTSSGA
  7261  SGITRAGPTS ETTTSLGGSG TTGAEIKSAA VPSGTTVAPG SSNSEATTSV GENGKTRGEI
  7321  ITDTTEGTSG KVLEPGSAHT EATTFPGGSG TTRAGPPGGT TGELSRMTII PGSSNTEATT
  7381  STKGTGTSGT GFKTGTSWVA PGTTVSPGSF STATISPGAS RTTGAAPAAE TTTSLEGGGT
  7441  TGAEIKSGAT SGVPGSKTGT AGVPSATTIA PGSSNSEATT SLGESGKTRV ETITGTTEGK
  7501  TLAAGSAHTE ATTFSGGSGS TRAGPLGGAS GTSGGYVPGR ETEPTTSIEE TGTSRTIFKT
  7561  VGITSAPGRQ AGTSVVAPST TVAPGSFSTA ATTSPGASGM TGVRTTSKTT TSLGGTGTTR
  7621  TEIKSGATTG APGIKTDIMG ESSRTTILSG SSNTEATNSI EETGTSGTGF KTAGITAAPG
  7681  KQAGTSGVAP GTTVAPGSFS TAATTSPGAS GVTGTGPTAE TTTFLGGSST TGAEIKSGAT
  7741  TGAPGSKTGT AKVLSGTTVA SGSSNSEATT FSGITEAVTV PSKNGSMTTA LGSQLSSSQT
  7801  VIPGSSGTIS HTTVAPGSSV TGTTTGASDD QVTGSKTGTT GVALSTTVAP GSSSTEATTS
  7861  TGVHRTTVVG QKTGATTRGS AKQGTRSTIE ATTSFRGTGT TGSGMNTGTT GVVSGNTISP
  7921  SSFNTEATSG TSERPNPGSE IGTTGIVSGT TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT
  7981  GITTGTTIVP GSFNTKATTS TDVGVATGVG MATGITNIIS GRSQPTGSKT GYTVTGSGTT
  8041  ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG ITGIPETSIS GPSKEASDKT TAPGPPTTVT
  8101  ASTGVKETSE TGVQTGSTLV TAGVPTRPQV SQPETTVVAT REVETENKTE CLASLPPAPV
  8161  CHGPLGEEKS PGDIWTANCH RGTCTDAKTI DCKPEECPSP PTCKTGEKLV KFQSNDTCCE
  8221  IGYCEPRTCL FNNTDYEIGA SFDDPSNPCV SYSCKDTGFA AVVQDCPKQT WCAEANRIYD
  8281  SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV QMAKCTGECE KTAKYNYDIL LLEHSCLCCR
  8341  EENYELRDIV LDCPDGSTIP YQYKHITTCS CLDICQLYTT FMYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 3.1 nTPM
testis: 0.9 nTPM
epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM

Single-cell type

salivary acinar cells: 704 nCPM
early spermatids: 67 nCPM
late spermatids: 28 nCPM
late primary spermatocytes: 24 nCPM
sertoli cells: 18 nCPM
respiratory ionocytes: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.1 nTPM
hypothalamus: 0.1 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.49

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC19 as an antibody target. Whether an autoantibody or antibody against MUC19 could matter depends on whether native MUC19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC19 is annotated as secreted, so native MUC19 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MUC19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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