C-terminal domain of methyl-CpG binding protein 2 and 3
PF14048
Definition
CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 PMID:16246164 and MBD3 PMID:12124384, the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex PMID:17694084, an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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