MBD3L3
Methyl-CpG-binding domain protein 3-like 3
Also known as: MB3L3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NE82
- Gene
- MBD3L3
- Ensembl
- ENSG00000182315
- Chromosome
- 19
- Canonical length
- 208 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
208 residues, UniProt reviewed canonical sequence.
>A6NE82|MBD3L3
1 MGEPAFTSFP SPPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP
61 VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP
121 GTAGESLDRA GAERVRSPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR
181 RVKKARERLA KALQADRLAR QAEMLTCRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MBD3L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 0.4 nTPM
Expression across tissuesHPA
Tissue
- testis: 0.4 nTPM
- bone marrow: 0.1 nTPM
- duodenum: 0.1 nTPM
- thymus: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- cardiomyocytes: 5.5 nCPM
- early primary spermatocytes: 4 nCPM
- undifferentiated spermatogonia: 3.6 nCPM
- colonocytes: 3.5 nCPM
- adipocytes: 2.6 nCPM
- thymocytes: 2.5 nCPM
Immune cell
- NK-cell: 0.3 nTPM
- myeloid DC: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- gdT-cell: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- white matter: 0.8 nTPM
- hippocampal formation: 0.6 nTPM
- pons: 0.6 nTPM
- cerebral cortex: 0.5 nTPM
- hypothalamus: 0.5 nTPM
- medulla oblongata: 0.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0.29
- gnomAD missense Z
- -0.32
OntologyGO
Biological processes
- DNA methylation-dependent constitutive heterochromatin formation
- negative regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MBD3L3 as an antibody target. Whether an autoantibody or antibody against MBD3L3 could matter depends on whether native MBD3L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MBD3L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MBD3L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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