MBD3L4
Methyl-CpG-binding domain protein 3-like 4
Also known as: MB3L4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NDZ8
- Gene
- MBD3L4
- Ensembl
- ENSG00000205718
- Chromosome
- 19
- Canonical length
- 208 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Cytosol
OverviewNCBI Gene
This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Aug 2009]
Canonical amino-acid sequenceUniProt
208 residues, UniProt reviewed canonical sequence.
>A6NDZ8|MBD3L4
1 MGEPAFTSFP SPPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP
61 VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP
121 GTAGESLDRA GAERVRIPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR
181 RVKKARERLA KALQADRLAR QAEMLTCRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MBD3L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- pancreatic acinar cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0.29
- gnomAD missense Z
- -0.02
OntologyGO
Biological processes
- DNA methylation-dependent constitutive heterochromatin formation
- negative regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MBD3L4 as an antibody target. Whether an autoantibody or antibody against MBD3L4 could matter depends on whether native MBD3L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MBD3L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MBD3L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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