Protein-arginine deiminase (PAD)

Definition

Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes [ec:3.5.3.15] catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O Protein L-citrulline + NH3. Several types are recognised (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen PMID:10092850.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• PADI1
• PADI2
• PADI3
• PADI4
• PADI6