Seroatlas · Human Serome Atlas

PADI6

Inactive protein-arginine deiminase type-6

Also known as: PADI6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6TGC4
Gene: PADI6
Ensembl: ENSG00000276747
Chromosome: 1
Canonical length: 694 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>Q6TGC4|PADI6
     1  MVSVEGRAMS FQSIIHLSLD SPVHAVCVLG TEICLDLSGC APQKCQCFTI HGSGRVLIDV
    61  ANTVISEKED ATIWWPLSDP TYATVKMTSP SPSVDADKVS VTYYGPNEDA PVGTAVLYLT
   121  GIEVSLEVDI YRNGQVEMSS DKQAKKKWIW GPSGWGAILL VNCNPADVGQ QLEDKKTKKV
   181  IFSEEITNLS QMTLNVQGPS CILKKYRLVL HTSKEESKKA RVYWPQKDNS STFELVLGPD
   241  QHAYTLALLG NHLKETFYVE AIAFPSAEFS GLISYSVSLV EESQDPSIPE TVLYKDTVVF
   301  RVAPCVFIPC TQVPLEVYLC RELQLQGFVD TVTKLSEKSN SQVASVYEDP NRLGRWLQDE
   361  MAFCYTQAPH KTTSLILDTP QAADLDEFPM KYSLSPGIGY MIQDTEDHKV ASMDSIGNLM
   421  VSPPVKVQGK EYPLGRVLIG SSFYPSAEGR AMSKTLRDFL YAQQVQAPVE LYSDWLMTGH
   481  VDEFMCFIPT DDKNEGKKGF LLLLASPSAC YKLFREKQKE GYGDALLFDE LRADQLLSNG
   541  REAKTIDQLL ADESLKKQNE YVEKCIHLNR DILKTELGLV EQDIIEIPQL FCLEKLTNIP
   601  SDQQPKRSFA RPYFPDLLRM IVMGKNLGIP KPFGPQIKGT CCLEEKICCL LEPLGFKCTF
   661  INDFDCYLTE VGDICACANI RRVPFAFKWW KMVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PADI6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

ovary: 5.5 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

oocytes: 83 nCPM
renal collecting duct intercalated cells: 0.3 nCPM
microglia: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM
proximal tubule cells: 0.2 nCPM
renal collecting duct principal cells: 0.2 nCPM

Immune cell

myeloid DC: 0.9 nTPM
gdT-cell: 0.5 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
total PBMC: 0.1 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PADI6.

Disease | AllUniProt

Conditions PADI6 is implicated in, by any mechanism.

Oocyte/zygote/embryo maturation arrest 16 (OZEMA16) MIM:617234

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Oocyte/zygote/embryo maturation arrest 16
PADI6-related disorder

Disease | ImmuneIEDB

Conditions an epitope on PADI6 was assayed in.

rheumatoid arthritis B cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cytoplasm organization
cytoskeleton organization
embryonic cleavage
epigenetic programming in the zygotic pronuclei
in utero embryonic development
protein storage
regulation of translation by machinery localization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PADI6 as an antibody target. Whether an autoantibody or antibody against PADI6 could matter depends on whether native PADI6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PADI6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PADI6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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