Core-2/I-Branching enzyme

Definition

This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme (eg [swissprot:Q06430]) and core-2 branching enzyme (eg [swissprot:Q02742]). I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development PMID:8449405. Core-2 branching enzyme forms crucial side-chain branches in O-glycans PMID:9915862. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus PMID:9915862.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• GCNT1
• GCNT2
• GCNT3
• GCNT4
• GCNT7
• XYLT1
• XYLT2