Seroatlas · Human Serome Atlas

GCNT4

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

Also known as: C2GNT3, GCNT4_HUMAN, LINC01336

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P109
Gene
GCNT4
Ensembl
ENSG00000176928
Chromosome
5
Canonical length
453 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in O-glycan processing and carbohydrate metabolic process. Predicted to act upstream of or within several processes, including inter-male aggressive behavior; neutrophil homeostasis; and thyroid hormone metabolic process. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q9P109|GCNT4
     1  MKIFKCYFKH TLQQKVFILF LTLWLLSLLK LLNVRRLFPQ KDIYLVEYSL STSPFVRNRY
    61  THVKDEVRYE VNCSGIYEQE PLEIGKSLEI RRRDIIDLED DDVVAMTSDC DIYQTLRGYA
   121  QKLVSKEEKS FPIAYSLVVH KDAIMVERLI HAIYNQHNIY CIHYDRKAPD TFKVAMNNLA
   181  KCFSNIFIAS KLEAVEYAHI SRLQADLNCL SDLLKSSIQW KYVINLCGQD FPLKSNFELV
   241  SELKKLNGAN MLETVKPPNS KLERFTYHHE LRRVPYEYVK LPIRTNISKE APPHNIQIFV
   301  GSAYFVLSQA FVKYIFNNSI VQDFFAWSKD TYSPDEHFWA TLIRVPGIPG EISRSAQDVS
   361  DLQSKTRLVK WNYYEGFFYP SCTGSHLRSV CIYGAAELRW LIKDGHWFAN KFDSKVDPIL
   421  IKCLAEKLEE QQRDWITLPS EKLFMDRNLT TTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCNT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 23 nTPM
  • small intestine: 19 nTPM
  • stomach: 18 nTPM
  • thymus: 14 nTPM
  • parathyroid gland: 9 nTPM
  • placenta: 6 nTPM

Single-cell type

  • foveolar cells: 114 nCPM
  • parietal cells: 78 nCPM
  • cytotrophoblasts: 71 nCPM
  • mucous neck cells: 66 nCPM
  • mast cells: 49 nCPM
  • endometrial luminal cells: 44 nCPM

Immune cell

  • basophil: 23 nTPM
  • T-reg: 18 nTPM
  • memory CD4 T-cell: 11 nTPM
  • naive CD4 T-cell: 11 nTPM
  • naive CD8 T-cell: 8.2 nTPM
  • MAIT T-cell: 5 nTPM

Brain region

  • cerebral cortex: 8.7 nTPM
  • basal ganglia: 5.4 nTPM
  • white matter: 4.8 nTPM
  • amygdala: 3.4 nTPM
  • hippocampal formation: 2.7 nTPM
  • medulla oblongata: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GCNT4 as an antibody target. Whether an autoantibody or antibody against GCNT4 could matter depends on whether native GCNT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GCNT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GCNT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GCNT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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