Seroatlas · Human Serome Atlas

GCNT7

Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7

Also known as: C20orf105, dJ1153D9.2, GCNT7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNI0
Gene: GCNT7
Ensembl: ENSG00000124091
Chromosome: 20
Canonical length: 430 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q6ZNI0|GCNT7
     1  MSQLRATKSG LVVRAVICIF IFLYLRNPTP AESEEEPAQP EVVECGFYPD ELCSALFEGK
    61  GAAPQIAKFC KTPHKSEIHA HLHTPGNCSR ISRGLHFITR PLSAEEGDFS LAYIITIHKE
   121  LAMFVQLLRA IYVPQNVYCI HVDEKAPMKY KTAVQTLVNC FENVFISSKT EKVAYAGFTR
   181  LQADINCMKV LVHSKFQWNY VINLCGQDFP IKTNREIIHY IRSKWSDKNI TPGVIQPLHI
   241  KSKTSQSHLE FVPKGSIYAP PNNRFKDKPP HNLTIYFGSA YYVLTRKFVE FILTDIHAKD
   301  MLQWSKDIRS PEQHYWVTLN RLKDAPGATP NAGWEGNVRA IKRKSEEGNV HDGCKGRYVE
   361  DICVYGPGDL PWLIQSPSLF ANKFEPSTDP LVVTCLERRH RLQVLRQAEV PIEPHWHFQQ
   421  QSHFNMRLNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCNT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4.1 nTPM
skin: 0.4 nTPM
appendix: 0.3 nTPM
retina: 0.3 nTPM
gallbladder: 0.2 nTPM
lymph node: 0.2 nTPM

Single-cell type

epicardial cells: 111 nCPM
cardiomyocytes: 55 nCPM
neutrophils: 29 nCPM
late spermatids: 25 nCPM
early spermatids: 23 nCPM
mast cells: 18 nCPM

Immune cell

neutrophil: 0.9 nTPM
basophil: 0.2 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

white matter: 4.4 nTPM
cerebellum: 3.8 nTPM
choroid plexus: 3.3 nTPM
medulla oblongata: 3.3 nTPM
cerebral cortex: 3.2 nTPM
midbrain: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.09
gnomAD missense Z: 0.7

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

acetylglucosaminyltransferase activity

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GCNT7 as an antibody target. Whether an autoantibody or antibody against GCNT7 could matter depends on whether native GCNT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GCNT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GCNT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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