Methyl-CpG binding domain

Definition

The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs PMID:8177735. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair PMID:8177735. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase PMID:10050851.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• BAZ2A
• BAZ2B
• MBD1
• MBD2
• MBD3
• MBD4
• MECP2
• SETDB1
• SETDB2