Immune receptor domain-containing protein

Definition

This family of proteins is involved in immune system processes, including the innate and adaptive immune responses. Members act as cell surface receptors that can enhance T-cell activation, regulate Toll-like receptor signaling, and mediate cytokine production. Some proteins in the family are implicated in the regulation of macrophage and dendritic cell activation, as well as in the phagocytosis of apoptotic cells and cellular debris. They may also participate in antigen presentation and the anti-viral response. Additionally, certain family members are involved in the regulation of microglial functions, such as proliferation, migration, phagocytosis, and the response to oxidative stress, which are crucial for brain homeostasis and the immune response in the central nervous system.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• NCR2
• TREM2
• TREML1
• TREML2
• TREML4