TREML4
Trem-like transcript 4 protein
Also known as: TLT4, TRML4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXN2
- Gene
- TREML4
- Ensembl
- ENSG00000188056
- Chromosome
- 6
- Canonical length
- 200 aa
- Protein class
- Predicted membrane proteins, Predicted secreted proteins
- Subcellular location
- Plasma membrane
- Secretome location
- Secreted - unknown location
OverviewNCBI Gene
Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum; endosome membrane; and lysosomal membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
200 residues, UniProt reviewed canonical sequence.
>Q6UXN2|TREML4
1 MAWGGVHTCC FHLCCCCSWP QGAVPEELHK HPGQTLLLQC QYSPKRGPYQ PKSWCQQTSP
61 SRCTLLVTSS KPWTAVQKSH YTIWDKPNAG FFNITMIQLT QNDSGFYWCG IYNASENIIT
121 VLRNISLVVS PAPTTSPMWT LPWLPTSTVL ITSPEGTSGH PSINGSETRK SRAPACLGSG
181 GPRFLVLVLC GLLLAKGLMLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TREML4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 1.9 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 1.9 nTPM
- bone marrow: 0.7 nTPM
- appendix: 0.3 nTPM
- spleen: 0.3 nTPM
- lung: 0.1 nTPM
- tongue: 0.1 nTPM
Single-cell type
- neutrophils: 32 nCPM
- choroid plexus epithelial cells: 12 nCPM
- pdcs: 3.8 nCPM
- monocytes: 2.8 nCPM
- neutrophil progenitors: 0.9 nCPM
- macrophages: 0.8 nCPM
Immune cell
- neutrophil: 8.3 nTPM
- eosinophil: 4.5 nTPM
- classical monocyte: 1.5 nTPM
- naive B-cell: 0.9 nTPM
- plasmacytoid DC: 0.7 nTPM
- myeloid DC: 0.5 nTPM
Brain region
- choroid plexus: 3.5 nTPM
- white matter: 1.1 nTPM
- cerebral cortex: 0.9 nTPM
- hypothalamus: 0.5 nTPM
- medulla oblongata: 0.5 nTPM
- thalamus: 0.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.76
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.43
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TREML4 as an antibody target. Whether an autoantibody or antibody against TREML4 could matter depends on whether native TREML4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TREML4 is annotated as secreted, so native TREML4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label TREML4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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