Seroatlas · Human Serome Atlas

STEAP1B

STEAP family member 1B

Also known as: STEAL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NZ63
Gene
STEAP1B
Ensembl
ENSG00000105889
Chromosome
7
Canonical length
245 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q6NZ63|STEAP1B
     1  MESRKDITNQ EEIWKMKPRR NLEDNDYLQT AHADEFDCPS ELQHAQELFP QWHLPIKIAA
    61  VMASLTFLYT LLREVIHPLA TSHQQYFYKI PILVINKVLP MVSITLLALV YLPGVIAAIV
   121  QVHNGTKYKK FPHWLDKWML TRKQFGLLSL FFAVLHAIYT LSYAMRRSYR YKLLNWAYQQ
   181  VQQNKEDAWI EHDVWRMEIY VSLGIVGLAI LALLAVTSIP SVSDSLTWRE FHYIQVHGRI
   241  NFLTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STEAP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
5.4 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 5.4 nTPM
  • spinal cord: 3.3 nTPM
  • midbrain: 2.5 nTPM
  • basal ganglia: 2.2 nTPM
  • hippocampal formation: 2.1 nTPM
  • testis: 2.1 nTPM

Single-cell type

  • enteric stem cells: 776 nCPM
  • paneth cells: 627 nCPM
  • enteric transient amplifying cells: 592 nCPM
  • epididymal efferent duct absorptive cells: 546 nCPM
  • epididymal basal cells: 518 nCPM
  • epididymal clear cells: 504 nCPM

Immune cell

  • memory B-cell: 8.4 nTPM
  • naive B-cell: 4.9 nTPM
  • total PBMC: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • white matter: 15 nTPM
  • choroid plexus: 11 nTPM
  • pons: 8.6 nTPM
  • basal ganglia: 7.7 nTPM
  • thalamus: 6.3 nTPM
  • midbrain: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STEAP1B as an antibody target. Whether an autoantibody or antibody against STEAP1B could matter depends on whether native STEAP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STEAP1B is annotated at the cell surface, where native STEAP1B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STEAP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STEAP1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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