Collagen and Collagen-like Structural Proteins
IPR050938
Definition
This family of proteins includes various types of collagen chains and collagen-like proteins that play crucial roles in the structural integrity and function of different tissues. Members of this family are involved in forming the extracellular matrix, providing tensile strength, and facilitating cell adhesion. They contribute to the formation of fibrillar and network-forming collagen, which are essential for the architecture of connective tissues, such as bone, cartilage, skin, and tendons. Some family members are involved in specialized functions, such as the formation of the egg case wall in certain species, participating in the protective cuticle layer in nematodes, or playing roles in the immune system by acting as pattern recognition receptors. Additionally, certain collagens may interact with components of the neuromuscular junction and influence the assembly of amyloid fibrils, indicating a diverse range of biological activities beyond structural support.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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