Seroatlas · Human Serome Atlas

MARCOL

MARCO-like protein

Also known as: MRCOL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUY1
Gene
MARCOL
Ensembl
ENSG00000248109
Chromosome
5
Canonical length
285 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>A0A1B0GUY1|MARCOL
     1  MRAFIFFLFM LLAMFSASST QISNTSVFKL EENPKPALIL EEKNEANHLG GQRDSNKQGG
    61  SYTQGNPGTF RLQGQPGYFN KLEKPRHFKQ GRAGVLNQPG ILKNSGKSNQ KGNPESSNKQ
   121  ENSGSSSQLG RPGISTQQGN PGSSDQQEKP GSFSQKVMVG SSSQQGKPGS SSQHGNLGSS
   181  TQKGNLGSSS LQGHLGLSSH QGKPESSGQQ GKPGSSSQQG NLGTSGQQEK PGSSSQQGKP
   241  GLSSHQGKPG SSSQQGNLHL SSQQGNQGPS SKQRKPGSSS RQGNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARCOL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 1.3 nTPM
  • epididymis: 0.9 nTPM
  • seminal vesicle: 0.6 nTPM
  • prostate: 0.4 nTPM
  • colon: 0.2 nTPM
  • cervix: 0.1 nTPM

Single-cell type

  • cardiomyocytes: 36 nCPM
  • proximal tubule cells: 13 nCPM
  • podocytes: 9.3 nCPM
  • renal connecting tubule cells: 6.4 nCPM
  • distal convoluted tubule cells: 6 nCPM
  • oocytes: 4.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.9 nTPM
  • medulla oblongata: 1.6 nTPM
  • pons: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • basal ganglia: 1.4 nTPM
  • midbrain: 1.4 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MARCOL as an antibody target. Whether an autoantibody or antibody against MARCOL could matter depends on whether native MARCOL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MARCOL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MARCOL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MARCOL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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