Seroatlas · Human Serome Atlas

COL23A1

Collagen alpha-1(XXIII) chain

Also known as: CONA1_HUMAN, DKFZp434K0621

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Y22
Gene: COL23A1
Ensembl: ENSG00000050767
Chromosome: 5
Canonical length: 540 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homotrimer

OverviewNCBI Gene

COL23A1 is a member of the transmembrane collagens, a subfamily of the nonfibrillar collagens that contain a single pass hydrophobic transmembrane domain (Banyard et al., 2003 [PubMed 12644459]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q86Y22|COL23A1
     1  MGPGERAGGG GDAGKGNAAG GGGGGRSATT AGSRAVSALC LLLSVGSAAA CLLLGVQAAA
    61  LQGRVAALEE ERELLRRAGP PGALDAWAEP HLERLLREKL DGLAKIRTAR EAPSECVCPP
   121  GPPGRRGKPG RRGDPGPPGQ SGRDGYPGPL GLDGKPGLPG PKGEKGAPGD FGPRGDQGQD
   181  GAAGPPGPPG PPGARGPPGD TGKDGPRGAQ GPAGPKGEPG QDGEMGPKGP PGPKGEPGVP
   241  GKKGDDGTPS QPGPPGPKGE PGSMGPRGEN GVDGAPGPKG EPGHRGTDGA AGPRGAPGLK
   301  GEQGDTVVID YDGRILDALK GPPGPQGPPG PPGIPGAKGE LGLPGAPGID GEKGPKGQKG
   361  DPGEPGPAGL KGEAGEMGLS GLPGADGLKG EKGESASDSL QESLAQLIVE PGPPGPPGPP
   421  GPMGLQGIQG PKGLDGAKGE KGASGERGPS GLPGPVGPPG LIGLPGTKGE KGRPGEPGLD
   481  GFPGPRGEKG DRSERGEKGE RGVPGRKGVK GQKGEPGPPG LDQPCPVGPD GLPVPGCWHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COL23A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 19 nTPM
heart muscle: 3 nTPM
retina: 1.9 nTPM
skin: 1.8 nTPM
stomach: 1.8 nTPM
bone marrow: 1.7 nTPM

Single-cell type

müller glia: 421 nCPM
bergmann glia: 310 nCPM
cardiomyocytes: 153 nCPM
erythrocyte progenitors: 142 nCPM
thymic myoid cells: 137 nCPM
neutrophil progenitors: 128 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 7.5 nTPM
cerebellum: 7.4 nTPM
cerebral cortex: 6.4 nTPM
basal ganglia: 5.2 nTPM
amygdala: 5 nTPM
pons: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COL23A1 as an antibody target. Whether an autoantibody or antibody against COL23A1 could matter depends on whether native COL23A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COL23A1 is annotated at the cell surface, where native COL23A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label COL23A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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