Seroatlas · Human Serome Atlas

KDM7A

Lysine-specific demethylase 7A

Also known as: JHDM1D, KDM7A_HUMAN, KIAA1718

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMT4
Gene: KDM7A
Ensembl: ENSG00000006459
Chromosome: 7
Canonical length: 941 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Predicted to be involved in chromatin remodeling; midbrain development; and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>Q6ZMT4|KDM7A
     1  MAGAAAAVAA GAAAGAAAAA VSVAAPGRAS APPPPPPVYC VCRQPYDVNR FMIECDICKD
    61  WFHGSCVGVE EHHAVDIDLY HCPNCAVLHG SSLMKKRRNW HRHDYTEIDD GSKPVQAGTR
   121  TFIKELRSRV FPSADEIIIK MHGSQLTQRY LEKHGFDVPI MVPKLDDLGL RLPSPTFSVM
   181  DVERYVGGDK VIDVIDVARQ ADSKMTLHNY VKYFMNPNRP KVLNVISLEF SDTKMSELVE
   241  VPDIAKKLSW VENYWPDDSV FPKPFVQKYC LMGVQDSYTD FHIDFGGTSV WYHVLWGEKI
   301  FYLIKPTDEN LARYESWSSS VTQSEVFFGD KVDKCYKCVV KQGHTLFVPT GWIHAVLTSQ
   361  DCMAFGGNFL HNLNIGMQLR CYEMEKRLKT PDLFKFPFFE AICWFVAKNL LETLKELRED
   421  GFQPQTYLVQ GVKALHTALK LWMKKELVSE HAFEIPDNVR PGHLIKELSK VIRAIEEENG
   481  KPVKSQGIPI VCPVSRSSNE ATSPYHSRRK MRKLRDHNVR TPSNLDILEL HTREVLKRLE
   541  MCPWEEDILS SKLNGKFNKH LQPSSTVPEW RAKDNDLRLL LTNGRIIKDE RQPFADQSLY
   601  TADSENEEDK RRTKKAKMKI EESSGVEGVE HEESQKPLNG FFTRVKSELR SRSSGYSDIS
   661  ESEDSGPECT ALKSIFTTEE SESSGDEKKQ EITSNFKEES NVMRNFLQKS QKPSRSEIPI
   721  KRECPTSTST EEEAIQGMLS MAGLHYSTCL QRQIQSTDCS GERNSLQDPS SCHGSNHEVR
   781  QLYRYDKPVE CGYHVKTEDP DLRTSSWIKQ FDTSRFHPQD LSRSQKCIRK EGSSEISQRV
   841  QSRNYVDSSG SSLQNGKYMQ NSNLTSGACQ ISNGSLSPER PVGETSFSVP LHPTKRPASN
   901  PPPISNQATK GKRPKKGMAT AKQRLGKILK LNRNGHARFF V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KDM7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
tongue: 12 nTPM
skeletal muscle: 11 nTPM
cervix: 9 nTPM
rectum: 8.8 nTPM
stomach: 8.8 nTPM

Single-cell type

neutrophils: 627 nCPM
neutrophil progenitors: 426 nCPM
esophageal apical cells: 319 nCPM
monocytes: 204 nCPM
foveolar cells: 202 nCPM
ocular epithelial cells: 197 nCPM

Immune cell

neutrophil: 2.2 nTPM
myeloid DC: 1.1 nTPM
naive B-cell: 1.1 nTPM
classical monocyte: 0.8 nTPM
basophil: 0.6 nTPM
NK-cell: 0.6 nTPM

Brain region

cerebral cortex: 12 nTPM
cerebellum: 12 nTPM
thalamus: 11 nTPM
white matter: 9.8 nTPM
pons: 9.4 nTPM
hippocampal formation: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.46
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KDM7A as an antibody target. Whether an autoantibody or antibody against KDM7A could matter depends on whether native KDM7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KDM7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KDM7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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