Seroatlas · Human Serome Atlas

RHOXF1

Rhox homeobox family member 1

Also known as: OTEX, PEPP1, RHXF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHV9
Gene: RHOXF1
Ensembl: ENSG00000101883
Chromosome: X
Canonical length: 184 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q8NHV9|RHOXF1
     1  MARSLVHDTV FYCLSVYQVK ISPTPQLGAA SSAEGHVGQG APGLMGNMNP EGGVNHENGM
    61  NRDGGMIPEG GGGNQEPRQQ PQPPPEEPAQ AAMEGPQPEN MQPRTRRTKF TLLQVEELES
   121  VFRHTQYPDV PTRRELAENL GVTEDKVRVW FKNKRARCRR HQRELMLANE LRADPDDCVY
   181  IVVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOXF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
cerebellum: 12 nTPM
hypothalamus: 3.7 nTPM
choroid plexus: 3.6 nTPM
ovary: 3.6 nTPM
cerebral cortex: 3 nTPM

Single-cell type

differentiating spermatogonia: 151 nCPM
undifferentiated spermatogonia: 150 nCPM
granulosa cells: 70 nCPM
adipocytes: 59 nCPM
pituitary stem cells: 49 nCPM
adrenal cortex cells: 48 nCPM

Immune cell

T-reg: 4.7 nTPM
memory CD4 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.2 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 4.1 nTPM
cerebral cortex: 3.1 nTPM
hypothalamus: 2.3 nTPM
midbrain: 2.3 nTPM
choroid plexus: 2.2 nTPM
medulla oblongata: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.77
gnomAD missense Z: -0.08
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOXF1 as an antibody target. Whether an autoantibody or antibody against RHOXF1 could matter depends on whether native RHOXF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOXF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHOXF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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