Seroatlas · Human Serome Atlas

ALX3

Homeobox protein aristaless-like 3

Also known as: ALX3_HUMAN, FND

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95076
Gene
ALX3
Ensembl
ENSG00000156150
Chromosome
1
Canonical length
343 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>O95076|ALX3
     1  MDPEHCAPFR VGPAPGPYVA SGDEPPGPQG TPAAAPHLHP APPRGPRLTR FPACGPLEPY
    61  LPEPAKPPAK YLQDLGPGPA LNGGHFYEGP AEAEEKTSKA ASFPQLPLDC RGGPRDGPSN
   121  LQGSPGPCLA SLHLPLSPGL PDSMELAKNK SKKRRNRTTF STFQLEELEK VFQKTHYPDV
   181  YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKIQEG RNPFTAAYDI SVLPRTDSHP
   241  QLQNSLWASP GSGSPGGPCL VSPEGIPSPC MSPYSHPHGS VAGFMGVPAP SAAHPGIYSI
   301  HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN WTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
6.8 nTPM

Expression across tissuesHPA

Tissue

  • skin: 6.8 nTPM
  • retina: 5.1 nTPM
  • skeletal muscle: 2.9 nTPM
  • choroid plexus: 2.7 nTPM
  • lymph node: 2.7 nTPM
  • small intestine: 2.7 nTPM

Single-cell type

  • oocytes: 14 nCPM
  • epicardial cells: 14 nCPM
  • cardiomyocytes: 10 nCPM
  • pericytes: 3.3 nCPM
  • fibroblasts: 2.5 nCPM
  • rod photoreceptor cells: 2.5 nCPM

Immune cell

  • naive CD8 T-cell: 0.4 nTPM
  • basophil: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • medulla oblongata: 8.6 nTPM
  • pons: 8.3 nTPM
  • choroid plexus: 7.5 nTPM
  • thalamus: 7.3 nTPM
  • cerebral cortex: 6.8 nTPM
  • basal ganglia: 6.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALX3.

Disease | AllUniProt

Conditions ALX3 is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 99 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Frontorhiny

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.02
gnomAD missense Z
0.45
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALX3 as an antibody target. Whether an autoantibody or antibody against ALX3 could matter depends on whether native ALX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALX3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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