Extracellular Matrix Assembly and Organization
IPR050525
Definition
The protein family is involved in the structural integrity and organization of extracellular matrices in various tissues. Members of this family are major components of cartilage extracellular matrix and are involved in matrix assembly, promoting cell adhesion and playing roles in the formation of filamentous networks. Some proteins within the family interact with collagen, integrating collagen bundles and contributing to cell-binding. Others are involved in the organization of skeletal muscles and the formation of neuromuscular junctions. Additionally, certain members have roles in hemostasis, acting as molecular bridges in platelet adhesion or as chaperones for coagulation factors. The family also includes proteins that regulate cell shape and motility, as well as the proliferation and differentiation of neural stem cells, indicating a broader significance in tissue development and maintenance.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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