Seroatlas · Human Serome Atlas

VIT

Vitrin

Also known as: VITRN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXI7
Gene: VIT
Ensembl: ENSG00000205221
Chromosome: 2
Canonical length: 678 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes an extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration. High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>Q6UXI7|VIT
     1  MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA GKIIDPEFIV
    61  KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG
   121  VQSLSLPRWR ESFIVLESKP KKGVTYPSAL TYSSSKSPAA QAGETTKAYQ RPPIPGTTAQ
   181  PVTLMQLLAV TVAVATPTTL PRPSPSAAST TSIPRPQSVG HRSQEMDLWS TATYTSSQNR
   241  PRADPGIQRQ DPSGAAFQKP VGADVSLGLV PKEELSTQSL EPVSLGDPNC KIDLSFLIDG
   301  STSIGKRRFR IQKQLLADVA QALDIGPAGP LMGVVQYGDN PATHFNLKTH TNSRDLKTAI
   361  EKITQRGGLS NVGRAISFVT KNFFSKANGN RSGAPNVVVV MVDGWPTDKV EEASRLARES
   421  GINIFFITIE GAAENEKQYV VEPNFANKAV CRTNGFYSLH VQSWFGLHKT LQPLVKRVCD
   481  TDRLACSKTC LNSADIGFVI DGSSSVGTGN FRTVLQFVTN LTKEFEISDT DTRIGAVQYT
   541  YEQRLEFGFD KYSSKPDILN AIKRVGYWSG GTSTGAAINF ALEQLFKKSK PNKRKLMILI
   601  TDGRSYDDVR IPAMAAHLKG VITYAIGVAW AAQEELEVIA THPARDHSFF VDEFDNLHQY
   661  VPRIIQNICT EFNSQPRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VIT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

tongue: 38 nTPM
ovary: 36 nTPM
adipose tissue: 34 nTPM
blood vessel: 18 nTPM
heart muscle: 18 nTPM
urinary bladder: 17 nTPM

Single-cell type

fibro-adipogenic progenitors: 352 nCPM
leydig cells: 268 nCPM
myosatellite cells: 222 nCPM
fibroblasts: 213 nCPM
bergmann glia: 145 nCPM
goblet cells: 73 nCPM

Immune cell

gdT-cell: 2.3 nTPM
naive CD8 T-cell: 1.3 nTPM
memory CD8 T-cell: 0.9 nTPM
total PBMC: 0.6 nTPM
NK-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 2.2 nTPM
cerebellum: 1.8 nTPM
basal ganglia: 1.2 nTPM
choroid plexus: 1.2 nTPM
thalamus: 0.9 nTPM
white matter: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -1.77
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glycosaminoglycan binding

Cellular components

interstitial matrix

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VIT as an antibody target. Whether an autoantibody or antibody against VIT could matter depends on whether native VIT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VIT is annotated as secreted, so native VIT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VIT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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