LIM/homeobox transcription factors
IPR050453
Definition
The LIM/homeobox protein family comprises transcription factors with diverse roles in embryonic development and cell differentiation. Members of the family are involved in specifying cell fates in various tissues, including the nervous system, limbs, gonads, and sensory organs. They regulate gene expression by binding to DNA, often acting synergistically with other transcription factors. LIM domains within these proteins typically contribute to transcriptional activation and can exert regulatory functions. The family plays critical roles in processes such as limb dorsalization, neuronal specification and migration, sensory neuron differentiation, and gonadal development. Some members are also implicated in mesoderm formation, neurogenesis, and the development of the pituitary gland and respiratory system.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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