LHX9

Protein identityUniProt · HPA

UniProt accession

Q9NQ69

Gene

LHX9

Ensembl

ENSG00000143355

Chromosome

1

Canonical length

397 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q9NQ69|LHX9
     1  MEIVGCRAED NSCPFRPPAM LFHGISGGHI QGIMEEMERR SKTEARLAKG AQLNGRDAGM
    61  PPLSPEKPAL CAGCGGKISD RYYLLAVDKQ WHLRCLKCCE CKLALESELT CFAKDGSIYC
   121  KEDYYRRFSV QRCARCHLGI SASEMVMRAR DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL
   181  VYCRAHFETL LQGEYPPQLS YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV
   241  NYNSGCNENE ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL
   301  AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS GALTPPGTAT
   361  TLTDLTNPTI TVVTSVTSNM DSHESGSPSQ TTLTNLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LHX9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LHX9.

Disease | ImmuneIEDB

Conditions an epitope on LHX9 was assayed in.

• narcolepsy T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.29

gnomAD pLI

0.98

gnomAD missense Z

1.08

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• female gonad development
• male gonad development
• negative regulation of DNA-templated transcription
• neuron differentiation
• regulation of transcription by RNA polymerase II
• dorsal spinal cord interneuron anterior axon guidance
• gonad morphogenesis

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• metal ion binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Zinc finger, LIM-type
• Homedomain-like superfamily
• Homeobox, conserved site
• LIM/homeobox transcription factors
• Homeodomain
• LIM domain

KeywordsUniProt

• DNA-binding
• Homeobox
• LIM domain
• Metal-binding
• Nucleus
• Repeat
• Zinc

InteractionsUniProt · HPA

Protein binding partners of LHX9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LDB1
• LDB2