LHX5

Protein identityUniProt · HPA

UniProt accession

Q9H2C1

Gene

LHX5

Ensembl

ENSG00000089116

Chromosome

12

Canonical length

402 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q9H2C1|LHX5
     1  MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL YCKNDFFRRF
    61  GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS TGEELYVIDE NKFVCKDDYL
   121  SSSSLKEGSL NSVSSCTDRS LSPDLQDALQ DDPKETDNST SSDKETANNE NEEQNSGTKR
   181  RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
   241  LSALGARRHA FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQGDYYAPG SNYDFFAHGP
   301  PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHAADNPR FTDMISHPDT PSPEPGLPGT
   361  LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA VW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LHX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

3.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.35

gnomAD pLI

0.95

gnomAD missense Z

2.17

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell proliferation in forebrain
• cerebellar Purkinje cell differentiation
• cerebellar Purkinje cell-granule cell precursor cell signaling
• forebrain neuron differentiation
• hippocampus development
• neuroblast proliferation
• neuron differentiation
• positive regulation of DNA-templated transcription
• regulation of cerebellar granule cell precursor proliferation
• regulation of neuroblast proliferation
• regulation of transcription by RNA polymerase II
• spinal cord association neuron differentiation

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Zinc finger, LIM-type
• Homedomain-like superfamily
• Homeobox, conserved site
• Lhx1/5, LIM domain 1
• Lhx1/5, LIM domain 2
• LIM/homeobox transcription factors
• Homeodomain
• LIM domain

KeywordsUniProt

• DNA-binding
• Homeobox
• LIM domain
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc