Ephrin receptor tyrosine kinases
IPR050449
Definition
The Ephrin receptor family is a group of receptor tyrosine kinases that bind to membrane-bound ephrin ligands on adjacent cells, facilitating contact-dependent bidirectional signaling. These interactions are crucial for various developmental processes, including axon guidance, synaptic plasticity, cell migration, and differentiation. The family is characterized by forward signaling through the receptor and reverse signaling through the ephrin ligand. Members of this family play roles in the nervous system, such as in the guidance of neuronal axons and the formation of dendritic spines and excitatory synapses. They are also involved in angiogenesis, heart morphogenesis, and the maintenance of satellite cells. Some receptors are promiscuous, binding both A and B ephrin ligands, while others have more specific interactions. Certain family members are kinase-defective but still participate in cell adhesion and migration regulation.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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