Major Facilitator Superfamily Sodium/Anion Cotransporter
IPR050382
Definition
The Major Facilitator Superfamily Sodium/Anion Cotransporter family is involved in the transport of various substrates across cellular membranes. Members of this family function as uniporters, symporters, and antiporters, often driven by electrochemical gradients. They play critical roles in transporting L-glutamate, phosphate, chloride, protons, potassium, sodium, and other anions. These transport activities are essential for processes such as synaptic transmission, cellular nutrient uptake, and ion homeostasis. Some members are involved in specialized functions like urate transport in the kidney, vesicular storage of neurotransmitters, and regulation of retinal vessel development. The activity of these transporters can be allosterically regulated by ions such as H+ and Cl-, and they are associated with various physiological functions in different tissues, including the nervous system, kidney, and chloroplasts in plants.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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