Seroatlas · Human Serome Atlas

SLC17A4

Probable small intestine urate exporter

Also known as: KIAA2138, S17A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2C5
Gene
SLC17A4
Ensembl
ENSG00000146039
Chromosome
6
Canonical length
497 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

497 residues, UniProt reviewed canonical sequence.

>Q9Y2C5|SLC17A4
     1  MSTGPDVKAT VGDISSDGNL NVAQEECSRK GFCSVRHGLA LILQLCNFSI YTQQMNLSIA
    61  IPAMVNNTAP PSQPNASTER PSTDSQGYWN ETLKEFKAMA PAYDWSPEIQ GIILSSLNYG
   121  SFLAPIPSGY VAGIFGAKYV VGAGLFISSF LTLFIPLAAN AGVALLIVLR IVQGIAQVMV
   181  LTGQYSIWVK WAPPLERSQL TTIAGSGSML GSFIVLLAGG LLCQTIGWPY VFYIFGGIGC
   241  ACCPLWFPLI YDDPVNHPFI SAGEKRYIVC SLAQQDCSPG WSLPIRAMIK SLPLWAILVS
   301  YFCEYWLFYT IMAYTPTYIS SVLQANLRDS GILSALPFVV GCICIILGGL LADFLLSRKI
   361  LRLITIRKLF TAIGVLFPSV ILVSLPWVRS SHSMTMTFLV LSSAISSFCE SGALVNFLDI
   421  APRYTGFLKG LLQVFAHIAG AISPTAAGFF ISQDSEFGWR NVFLLSAAVN ISGLVFYLIF
   481  GRADVQDWAK EQTFTHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC17A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • liver: 48 nTPM
  • small intestine: 30 nTPM
  • duodenum: 27 nTPM
  • rectum: 25 nTPM
  • pancreas: 21 nTPM
  • colon: 19 nTPM

Single-cell type

  • cholangiocytes: 170 nCPM
  • colonocytes: 156 nCPM
  • enterocytes: 83 nCPM
  • hepatocytes: 73 nCPM
  • pancreatic duct cells: 57 nCPM
  • goblet cells: 34 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 1.5 nTPM
  • pons: 0.6 nTPM
  • cerebral cortex: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC17A4 as an antibody target. Whether an autoantibody or antibody against SLC17A4 could matter depends on whether native SLC17A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC17A4 is annotated at the cell surface, where native SLC17A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC17A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC17A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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