Seroatlas · Human Serome Atlas

SLC17A2

Sodium-dependent phosphate transport protein 3

Also known as: NPT3, NPT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00624
Gene: SLC17A2
Ensembl: ENSG00000112337
Chromosome: 6
Canonical length: 439 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable urate transmembrane transporter activity. Predicted to be involved in phosphate-containing compound metabolic process and sodium ion transport. Predicted to be located in plasma membrane. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>O00624|SLC17A2
     1  MDGKPATRKG PDFCSLRYGL ALIMHFSNFT MITQRVSLSI AIIAMVNTTQ QQGLSNASTE
    61  GPVADAFNNS SISIKEFDTK ASVYQWSPET QGIIFSSINY GIILTLIPSG YLAGIFGAKK
   121  MLGAGLLISS LLTLFTPLAA DFGVILVIMV RTVQGMAQGM AWTGQFTIWA KWAPPLERSK
   181  LTTIAGSGSA FGSFIILCVG GLISQALSWP FIFYIFGSTG CVCCLLWFTV IYDDPMHHPC
   241  ISVREKEHIL SSLAQQPSSP GRAVPIKAMV TCLPLWAIFL GFFSHFWLCT IILTYLPTYI
   301  STLLHVNIRD SGVLSSLPFI AAASCTILGG QLADFLLSRN LLRLITVRKL FSSLGLLLPS
   361  ICAVALPFVA SSYVITIILL ILIPGTSNLC DSGFIINTLD IAPRYASFLM GISRGFGLIA
   421  GIISSTATGF LISQVGPVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC17A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

liver: 74 nTPM
kidney: 0.4 nTPM
testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

hepatocytes: 42 nCPM
vascular endothelial cells: 2.9 nCPM
proximal tubule cells: 2.3 nCPM
cholangiocytes: 2 nCPM
kupffer cells: 1 nCPM
undifferentiated spermatogonia: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC17A2 as an antibody target. Whether an autoantibody or antibody against SLC17A2 could matter depends on whether native SLC17A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC17A2 is annotated at the cell surface, where native SLC17A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC17A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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