Bifunctional lipid A modification and metabolic enzymes
IPR050177
Definition
This family of proteins includes enzymes with bifunctional activities, primarily involved in the modification of lipid A, which is a component of the bacterial outer membrane. The enzymes catalyze the oxidative decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose, resulting in UDP-L-4-formamido-arabinose. These modifications are crucial for bacterial resistance to polymyxin and other cationic antimicrobial peptides. Additionally, the family encompasses various dehydrogenases involved in steroid biosynthesis, as well as epimerases/dehydratases that participate in carbohydrate and nucleotide sugar metabolism, contributing to diverse biological processes such as cell wall biosynthesis and steroid hormone production.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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