Aminoacid dehydrogenase-like, N-terminal domain superfamily

Definition

This superfamily represents a domain found at the N-terminal of a wide range of dehydrogenases from bacteria, eukaryotes and archaea, including tetrahydrofolate dehydrogenase/cyclohydrolase PMID:9519408, methylene-tetrahydromethanopterin dehydrogenase PMID:12176390, shikimate dehydrogenase [[cite:PMID:15735308], [cite:PMID:12906831]], amino acid dehydrogenases (Glutamate/phenylalanine/leucine/valine dehydrogenases) and malic enzymes PMID:10477256. It has a core fold of three layers in an α/β/α configuration. Its central parallel β-sheet of four strands has the order 2134. In amino acid dehydrogenases, this domain participates in dimerisation PMID:8591046.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• GLUD1
• GLUD2
• ME1
• ME2
• ME3
• MTHFD1
• MTHFD1L
• MTHFD2
• MTHFD2L