DnaJ homolog subfamily B member 2/6-like
IPR043183
Definition
DNAJB2 (also known as HSJ-1) contains an N-terminal J-domain and the C-terminal UIMs (ubiquitin (Ub)-interacting motifs)-containing domain. It binds and stimulates ATPase activity of HSP70 through its J-domain PMID:22219199. It also binds to polyUb chains through its UIM domain and contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins [[cite:PMID:15936278], [cite:PMID:21625540]]. DNAJB6 (also known as HSJ-2) plays an indispensable role in the organization of KRT8/KRT18 filaments. It acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. DNAJB6 is able to suppress aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. It also has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 [[cite:PMID:10954706], [cite:PMID:22366786]]. DNAJB8 is also a suppressor of aggregation and toxicity of disease-associated polyglutamine proteins PMID:20159555.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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