Seroatlas · Human Serome Atlas

DNAJB7

DnaJ homolog subfamily B member 7

Also known as: DNJB7_HUMAN, HSC3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6W7
Gene: DNAJB7
Ensembl: ENSG00000172404
Chromosome: 22
Canonical length: 309 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this intronless gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q7Z6W7|DNAJB7
     1  MVDYYEVLGL QRYASPEDIK KAYHKVALKW HPDKNPENKE EAERKFKEVA EAYEVLSNDE
    61  KRDIYDKYGT EGLNGGGSHF DDECEYGFTF HKPDDVFKEI FHERDPFSFH FFEDSLEDLL
   121  NRPGSSYGNR NRDAGYFFST ASEYPIFEKF SSYDTGYTSQ GSLGHEGLTS FSSLAFDNSG
   181  MDNYISVTTS DKIVNGRNIN TKKIIESDQE REAEDNGELT FFLVNSVANE EGFAKECSWR
   241  TQSFNNYSPN SHSSKHVSQY TFVDNDEGGI SWVTSNRDPP IFSAGVKEGG KRKKKKRKEV
   301  QKKSTKRNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
cerebellum: 0.7 nTPM
retina: 0.7 nTPM
bone marrow: 0.5 nTPM
small intestine: 0.5 nTPM
duodenum: 0.4 nTPM

Single-cell type

early spermatids: 726 nCPM
late spermatids: 118 nCPM
late primary spermatocytes: 34 nCPM
epicardial cells: 16 nCPM
adipocytes: 10 nCPM
retinal ganglion cells: 7.7 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebellum: 3.9 nTPM
white matter: 3.5 nTPM
choroid plexus: 3.1 nTPM
cerebral cortex: 3 nTPM
basal ganglia: 2.7 nTPM
thalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.76
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Chaperone

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJB7 as an antibody target. Whether an autoantibody or antibody against DNAJB7 could matter depends on whether native DNAJB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJB7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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