Seroatlas · Human Serome Atlas

DNAJB3

DnaJ homolog subfamily B member 3

Also known as: DNJB3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWF6
Gene: DNAJB3
Canonical length: 145 aa

OverviewNCBI Gene

No narrative summary is available for DNAJB3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q8WWF6|DNAJB3
     1  MVDYYEVLDV PRQASSEAIK KAYRKLALKW HPDKNPENKE EAERRFKQVA EAYEVLSDAK
    61  KRDIYDRYGE AGAEGGCTGG RPFEDPFEYV FSFRDPADVF REFFGGQDPF SFDLLGNPLE
   121  NILGGSEELL GKQKQSVCTP FLCLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of inclusion body assembly

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Chaperone

InteractionsUniProt · HPA

Protein binding partners of DNAJB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

USP8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJB3 as an antibody target. Whether an autoantibody or antibody against DNAJB3 could matter depends on whether native DNAJB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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