ILEI/PANDER domain
IPR039477
Definition
This entry represents the ILEI/PANDER domain found in FAM3 family members and related proteins. Both PANDER and ILEI share a similar β-β-α fold, strikingly different from the classical cytokines PMID:23333428. FAM3C, also known as interleukin-like EMT inducer ILEI, is a secreted signaling protein involved in epithelial-mesenchymal transition and tumor progression PMID:28751379. FAM3B, also known as PANDER (PANcreatic DERived factor), is a cytokine-like protein that induces apoptosis of insulin-secreting beta-cells PMID:12941769 and functions as a hormone by regulating glucose levels PMID:21664909.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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