Seroatlas · Human Serome Atlas

FAM3A

Protein FAM3A

Also known as: 2-19, DXS560S, FAM3A_HUMAN, XAP-7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98173
Gene: FAM3A
Ensembl: ENSG00000071889
Chromosome: X
Canonical length: 230 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Nucleoli rim,Mitotic chromosome
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>P98173|FAM3A
     1  MRLAGPLRIV VLVVSVGVTW IVVSILLGGP GSGFPRIQQL FTSPESSVTA APRARKYKCG
    61  LPQPCPEEHL AFRVVSGAAN VIGPKICLED KMLMSSVKDN VGRGLNIALV NGVSGELIEA
   121  RAFDMWAGDV NDLLKFIRPL HEGTLVFVAS YDDPATKMNE ETRKLFSELG SRNAKELAFR
   181  DSWVFVGAKG VQNKSPFEQH VKNSKHSNKY EGWPEALEME GCIPRRSTAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

liver: 61 nTPM
heart muscle: 56 nTPM
spinal cord: 55 nTPM
pancreas: 51 nTPM
ovary: 49 nTPM
midbrain: 46 nTPM

Single-cell type

esophageal apical cells: 132 nCPM
enterocytes: 118 nCPM
syncytiotrophoblasts: 90 nCPM
esophageal suprabasal cells: 90 nCPM
goblet cells: 69 nCPM
colonocytes: 67 nCPM

Immune cell

basophil: 23 nTPM
eosinophil: 15 nTPM
plasmacytoid DC: 15 nTPM
gdT-cell: 13 nTPM
MAIT T-cell: 13 nTPM
intermediate monocyte: 13 nTPM

Brain region

white matter: 64 nTPM
medulla oblongata: 56 nTPM
cerebellum: 51 nTPM
basal ganglia: 47 nTPM
cerebral cortex: 45 nTPM
midbrain: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.67
gnomAD missense Z: 0.93
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM3A as an antibody target. Whether an autoantibody or antibody against FAM3A could matter depends on whether native FAM3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM3A is annotated as secreted, so native FAM3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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