FAM3D
Protein FAM3D
Also known as: EF7, FAM3D_HUMAN, OIT1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96BQ1
- Gene
- FAM3D
- Ensembl
- ENSG00000198643
- Chromosome
- 3
- Canonical length
- 224 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Predicted to enable cytokine activity. Involved in negative regulation of insulin secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
224 residues, UniProt reviewed canonical sequence.
>Q96BQ1|FAM3D
1 MRVSGVLRLL ALIFAIVTTW MFIRSYMSFS MKTIRLPRWL AASPTKEIQV KKYKCGLIKP
61 CPANYFAFKI CSGAANVVGP TMCFEDRMIM SPVKNNVGRG LNIALVNGTT GAVLGQKAFD
121 MYSGDVMHLV KFLKEIPGGA LVLVASYDDP GTKMNDESRK LFSDLGSSYA KQLGFRDSWV
181 FIGAKDLRGK SPFEQFLKNS PDTNKYEGWP ELLEMEGCMP PKPFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 459 nTPM
Expression across tissuesHPA
Tissue
- rectum: 459 nTPM
- salivary gland: 441 nTPM
- colon: 339 nTPM
- esophagus: 270 nTPM
- small intestine: 85 nTPM
- duodenum: 84 nTPM
Single-cell type
- esophageal apical cells: 4,926 nCPM
- goblet cells: 1,152 nCPM
- colonocytes: 944 nCPM
- enteric transient amplifying cells: 519 nCPM
- respiratory secretory cells: 517 nCPM
- enteric stem cells: 510 nCPM
Immune cell
- neutrophil: 3.7 nTPM
- classical monocyte: 0.9 nTPM
- intermediate monocyte: 0.9 nTPM
- myeloid DC: 0.4 nTPM
- total PBMC: 0.4 nTPM
- non-classical monocyte: 0.3 nTPM
Brain region
- cerebral cortex: 0.7 nTPM
- thalamus: 0.6 nTPM
- midbrain: 0.5 nTPM
- amygdala: 0.4 nTPM
- hippocampal formation: 0.4 nTPM
- choroid plexus: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.21
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- aorta development
- negative regulation of insulin secretion
- neutrophil homeostasis
- neutrophil migration
- positive regulation of macrophage antigen processing and presentation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM3D as an antibody target. Whether an autoantibody or antibody against FAM3D could matter depends on whether native FAM3D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM3D is annotated as secreted, so native FAM3D circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label FAM3D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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