Seroatlas · Human Serome Atlas

SORCS1

VPS10 domain-containing receptor SorCS1

Also known as: SORC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WY21
Gene: SORCS1
Ensembl: ENSG00000108018
Chromosome: 10
Canonical length: 1168 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1168 residues, UniProt reviewed canonical sequence.

>Q8WY21|SORCS1
     1  MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG
    61  RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER
   121  GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW
   181  SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK
   241  RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA
   301  EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ
   361  PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE
   421  NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL
   481  ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI
   541  IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM
   601  KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL
   661  VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP
   721  CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG
   781  VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG
   841  IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV
   901  TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG
   961  NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI
  1021  LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL
  1081  VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRRVALPS PPSPSTQPGD
  1141  SSLRLQRARH ATPPSTPKRG SAGAQYAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SORCS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 10 nTPM
thyroid gland: 10 nTPM
colon: 9 nTPM
retina: 8.9 nTPM
cerebral cortex: 7.1 nTPM
kidney: 4.4 nTPM

Single-cell type

schwann cells: 1,154 nCPM
proximal tubule cells: 1,016 nCPM
müller glia: 587 nCPM
brain inhibitory neurons: 509 nCPM
oligodendrocyte progenitor cells: 495 nCPM
retinal ganglion cells: 321 nCPM

Immune cell

intermediate monocyte: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 30 nTPM
white matter: 22 nTPM
basal ganglia: 21 nTPM
hypothalamus: 21 nTPM
midbrain: 18 nTPM
pons: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SORCS1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 206 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Alzheimer disease 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.56
gnomAD missense Z: 1.3
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

neuropeptide receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SORCS1 as an antibody target. Whether an autoantibody or antibody against SORCS1 could matter depends on whether native SORCS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SORCS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SORCS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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