Seroatlas · Human Serome Atlas

SIRT3

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Also known as: SIR2L3, SIR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NTG7
Gene
SIRT3
Ensembl
ENSG00000142082
Chromosome
11
Canonical length
399 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q9NTG7|SIRT3
     1  MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL RGSHGARGEP
    61  LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR SISFSVGASS VVGSGGSSDK
   121  GKLSLQDVAE LIRARACQRV VVMVGAGIST PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF
   181  ELPFFFHNPK PFFTLAKELY PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP
   241  ASKLVEAHGT FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ
   301  RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP LAWHPRSRDV
   361  AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 38 nTPM
  • basal ganglia: 31 nTPM
  • choroid plexus: 30 nTPM
  • cerebral cortex: 27 nTPM
  • skeletal muscle: 26 nTPM
  • retina: 25 nTPM

Single-cell type

  • retinal ganglion cells: 62 nCPM
  • rod photoreceptor cells: 50 nCPM
  • ependymal cells: 42 nCPM
  • epididymal principal cells: 42 nCPM
  • breast myoepithelial cells: 41 nCPM
  • myonuclei: 38 nCPM

Immune cell

  • NK-cell: 8.1 nTPM
  • non-classical monocyte: 6.7 nTPM
  • naive CD4 T-cell: 5.9 nTPM
  • memory B-cell: 5.4 nTPM
  • naive CD8 T-cell: 4.9 nTPM
  • plasmacytoid DC: 4.8 nTPM

Brain region

  • basal ganglia: 51 nTPM
  • cerebral cortex: 51 nTPM
  • choroid plexus: 46 nTPM
  • hippocampal formation: 43 nTPM
  • white matter: 39 nTPM
  • amygdala: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIRT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRT3 as an antibody target. Whether an autoantibody or antibody against SIRT3 could matter depends on whether native SIRT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIRT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIRT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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