Inositol monophosphatase, conserved site
IPR020550
Definition
This entry represents a conserved signature pattern found within the inositol monophosphatase family of proteins. It is suggested PMID:1660408 that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules. It has been shown that several proteins share two sequence motifs PMID:1660408. Two of these proteins, vertebrate and plant inositol monophosphatase ([ec:3.1.3.25]), and vertebrate inositol polyphosphate 1-phosphatase ([ec:3.1.3.57]), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirement for metal ions (Mg2 is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) PMID:7761465. The function of the other proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules PMID:1660408. Structural analysis of these proteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivity to Li+. The targets and mechanism of action of Li+ are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression PMID:2553271.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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