Seroatlas · Human Serome Atlas

INPP1

Inositol polyphosphate 1-phosphatase

Also known as: INPP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49441
Gene
INPP1
Ensembl
ENSG00000151689
Chromosome
2
Canonical length
399 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>P49441|INPP1
     1  MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV
    61  IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA
   121  LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ
   181  CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR
   241  NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG
   301  LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA
   361  AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 69 nTPM
  • testis: 49 nTPM
  • urinary bladder: 39 nTPM
  • parathyroid gland: 39 nTPM
  • spinal cord: 37 nTPM
  • midbrain: 36 nTPM

Single-cell type

  • late spermatids: 1,285 nCPM
  • early spermatids: 898 nCPM
  • esophageal suprabasal cells: 352 nCPM
  • late primary spermatocytes: 204 nCPM
  • esophageal basal cells: 188 nCPM
  • esophageal apical cells: 160 nCPM

Immune cell

  • eosinophil: 96 nTPM
  • basophil: 26 nTPM
  • T-reg: 20 nTPM
  • NK-cell: 16 nTPM
  • myeloid DC: 8.7 nTPM
  • classical monocyte: 8.4 nTPM

Brain region

  • white matter: 73 nTPM
  • hypothalamus: 51 nTPM
  • basal ganglia: 48 nTPM
  • cerebral cortex: 44 nTPM
  • thalamus: 43 nTPM
  • medulla oblongata: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
1.18
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INPP1 as an antibody target. Whether an autoantibody or antibody against INPP1 could matter depends on whether native INPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INPP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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