Seroatlas · Human Serome Atlas

BPNT1

3'(2'),5'-bisphosphate nucleotidase 1

Also known as: BPNT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95861
Gene
BPNT1
Ensembl
ENSG00000162813
Chromosome
1
Canonical length
308 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>O95861|BPNT1
     1  MASSNTVLMR LVASAYSIAQ KAGMIVRRVI AEGDLGIVEK TCATDLQTKA DRLAQMSICS
    61  SLARKFPKLT IIGEEDLPSE EVDQELIEDS QWEEILKQPC PSQYSAIKEE DLVVWVDPLD
   121  GTKEYTEGLL DNVTVLIGIA YEGKAIAGVI NQPYYNYEAG PDAVLGRTIW GVLGLGAFGF
   181  QLKEVPAGKH IITTTRSHSN KLVTDCVAAM NPDAVLRVGG AGNKIIQLIE GKASAYVFAS
   241  PGCKKWDTCA PEVILHAVGG KLTDIHGNVL QYHKDVKHMN SAGVLATLRN YDYYASRVPE
   301  SIKNALVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPNT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 43 nTPM
  • tonsil: 41 nTPM
  • duodenum: 41 nTPM
  • colon: 35 nTPM
  • lymph node: 32 nTPM
  • rectum: 30 nTPM

Single-cell type

  • enterocytes: 61 nCPM
  • colonocytes: 51 nCPM
  • syncytiotrophoblasts: 39 nCPM
  • gastric progenitor cells: 39 nCPM
  • lacrimal acinar cells: 24 nCPM
  • respiratory ionocytes: 23 nCPM

Immune cell

  • memory B-cell: 21 nTPM
  • basophil: 21 nTPM
  • naive B-cell: 17 nTPM
  • naive CD4 T-cell: 15 nTPM
  • T-reg: 15 nTPM
  • NK-cell: 14 nTPM

Brain region

  • white matter: 19 nTPM
  • basal ganglia: 15 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 15 nTPM
  • cerebellum: 15 nTPM
  • choroid plexus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BPNT1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 42 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
1.36
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPNT1 as an antibody target. Whether an autoantibody or antibody against BPNT1 could matter depends on whether native BPNT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPNT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BPNT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BPNT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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