Argonaute, linker 1 domain

Definition

ArgoL1 is a region found in argonaute PMID:16216572 proteins. It normally co-occurs with BAG domain ([interpro:IPR003103]) and Piwi domain ([interpro:IPR003165]). It is a linker region between the N-terminal and the PAZ domains. It contains an α-helix packed against a three-stranded antiparallel β-sheet with two long β-strands (β8 and β9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold PMID:16061186.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• AGO1
• AGO2
• AGO3
• AGO4
• PIWIL1
• PIWIL2